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PLA2G10 and CATSPER1
Data Source:
BioGRID
(two hybrid)
PLA2G10
CATSPER1
Description
phospholipase A2 group X
cation channel sperm associated 1
Image
No pdb structure
GO Annotations
Cellular Component
Acrosomal Vesicle
Extracellular Region
Extracellular Space
Lysosome
Plasma Membrane
Motile Cilium
CatSper Complex
Molecular Function
1-alkyl-2-acetylglycerophosphocholine Esterase Activity
Phospholipase Activity
Phospholipase A2 Activity
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Calcium-dependent Phospholipase A2 Activity
Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine)
Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
Calcium Activated Cation Channel Activity
Voltage-gated Calcium Channel Activity
Protein Binding
Biological Process
Phospholipid Metabolic Process
Phosphatidic Acid Biosynthetic Process
Phosphatidylserine Metabolic Process
Axon Guidance
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Lipid Storage
Arachidonic Acid Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Prostaglandin Secretion
Low-density Lipoprotein Particle Remodeling
Phosphatidylcholine Catabolic Process
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylinositol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Cholesterol Homeostasis
Regulation Of Macrophage Activation
Negative Regulation Of DNA-binding Transcription Factor Activity
Phosphatidylethanolamine Metabolic Process
Phosphatidylcholine Metabolic Process
Phosphatidylglycerol Metabolic Process
Phosphatidic Acid Metabolic Process
Arachidonic Acid Secretion
Defense Response To Virus
Lysophospholipid Transport
Platelet Activating Factor Catabolic Process
Positive Regulation Of Arachidonic Acid Secretion
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Acrosome Reaction
Calcium Ion Transport
Multicellular Organism Development
Spermatogenesis
Cell Differentiation
Flagellated Sperm Motility
Response To Progesterone
Regulation Of Ion Transmembrane Transport
Sperm-egg Recognition
Regulation Of Cilium Beat Frequency Involved In Ciliary Motility
Calcium Ion Transmembrane Transport
Pathways
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Sperm Motility And Taxes
Drugs
Varespladib methyl
Crotalus adamanteus antivenin
Agkistrodon piscivorus antivenin
Diseases
GWAS
Cholesteryl ester levels (
31551469
)
Glycerophospholipid levels (
26068415
)
Acne (severe) (
24927181
)
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Height (
31562340
)
Interacting Genes
49 interacting genes:
AGXT
AQP1
ARID5A
ATXN1
BAG3
BEX2
C1orf94
CATSPER1
CCDC120
CREB5
CYSRT1
FAM222B
FOXH1
GATA5
GNE
HGS
HOXC8
HR
HSF4
INCA1
KPRP
KRTAP11-1
KRTAP26-1
LCE1A
LCE1C
LCE2A
LCE2B
LCE2D
MAL
MAPKBP1
MGAT5B
MYO10
NOXA1
NTAQ1
OTX1
PITX1
PLA2R1
POU4F3
PPP1R32
ROR2
SNRPC
SPAG8
STK16
TBX6
TFG
TLX3
VGLL3
VPS37C
ZC3H10
116 interacting genes:
ABLIM3
ADAMTSL4
AGR2
AGR3
AJUBA
AKAP8L
APOA2
ARID5A
BEGAIN
C11orf1
C11orf16
C9orf24
CARD10
CDPF1
CHIC2
CHRD
CPSF7
CTBP2
CYSRT1
EFEMP2
EMD
EYA2
FHL5
FRS3
FST
GLI1
HNRNPH1
HOXA1
IKZF3
KHDRBS2
KPRP
KRT31
KRTAP1-1
KRTAP1-3
KRTAP1-5
KRTAP10-1
KRTAP10-10
KRTAP10-11
KRTAP10-3
KRTAP10-4
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP17-1
KRTAP19-5
KRTAP19-6
KRTAP19-7
KRTAP2-3
KRTAP2-4
KRTAP3-2
KRTAP4-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-7
KRTAP5-11
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LASP1
LCE1D
LCE1E
LCE1F
LCE2C
LIMS1
LZTS2
MDFI
MTUS2
MYCL
NBPF19
NOTCH2NLA
PAK5
PDLIM7
PLA2G10
PLAGL2
PLSCR1
PLSCR3
PMF1-BGLAP
PPP1R32
PTPN21
RFX6
RGS19
RGS20
RIMBP3
RSPO2
SCRG1
SIVA1
SORBS3
SPRY2
SPRY3
SSC4D
TGFB1
TNS2
TRAF2
TRIM27
TRIM42
TRIM8
TRIP6
TSPAN4
VWC2
ZBTB42
ZIM2
ZNF688
ZNF774
ZNF837
Entrez ID
8399
117144
HPRD ID
04674
09396
Ensembl ID
ENSG00000069764
ENSG00000175294
Uniprot IDs
O15496
Q8NEC5
PDB IDs
1LE6
1LE7
4UY1
5G3M
5OW8
5OWC
6G5J
Enriched GO Terms of Interacting Partners
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