PLA2G10 and KRTAP11-1

Data Source:
BioGRID (two hybrid)

		PLA2G10	KRTAP11-1
Description		phospholipase A2 group X	keratin associated protein 11-1
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome	Cytosol Intermediate Filament
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Protein Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylserine Metabolic Process Axon Guidance Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Arachidonic Acid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Macrophage Activation Negative Regulation Of DNA-binding Transcription Factor Activity Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonic Acid Secretion Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cholesterol Efflux Positive Regulation Of Acrosome Reaction	Keratinization
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Keratinization
Drugs		Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
Diseases
GWAS		Cholesteryl ester levels ( 31551469) Glycerophospholipid levels ( 26068415)	Height ( 28552196)
Interacting Genes		49 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE HGS HOXC8 HR HSF4 INCA1 KPRP KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE2A LCE2B LCE2D MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 POU4F3 PPP1R32 ROR2 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10	104 interacting genes: AGR3 ANAPC11 ANKS1A ASB13 ATG9A ATXN1L BEX2 CERK CFP CHERP CRYBA1 CRYBA2 CSKMT CYSRT1 DHRS1 DTX2 DUSP21 EFEMP2 ENKD1 ETFDH FAM222B FANCL FASLG FBLN1 FNDC3B FOXH1 FRS3 GATA2 GNE GPS2 GPSM3 GRN HEY2 HOXA1 HOXC8 HR KLHL38 KRT83 KRTAP10-5 KRTAP10-8 KRTAP12-1 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP4-11 KRTAP4-2 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1F LCE2A LCE3A LCE3C LGALS4 LIMS3 LIMS4 LMO4 MEIS2 MICOS10-NBL1 NBL1 NUFIP2 OIT3 OLIG3 OR7A17 OTX1 PCSK5 PLA2G10 PLSCR3 RBPMS RBPMS2 RNF38 SLC13A5 SNRPC SPAG8 SPRY1 STK16 TBX6 TEKT4 TENT5D TFAP2D TLE5 TLX3 TNS2 TRIM54 VASN VENTX VGLL3 VWC2L WWOX YIPF3 ZDHHC17 ZIC1
Entrez ID		8399	337880
HPRD ID		04674	11196
Ensembl ID		ENSG00000069764	ENSG00000182591
Uniprot IDs		O15496	Q8IUC1
PDB IDs		1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J
Enriched GO Terms of Interacting Partners?
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