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PLA2G10 and POU4F3
Data Source:
BioGRID
(two hybrid)
PLA2G10
POU4F3
Description
phospholipase A2 group X
POU class 4 homeobox 3
Image
No pdb structure
GO Annotations
Cellular Component
Acrosomal Vesicle
Extracellular Region
Extracellular Space
Lysosome
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
1-alkyl-2-acetylglycerophosphocholine Esterase Activity
Phospholipase Activity
Phospholipase A2 Activity
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Calcium-dependent Phospholipase A2 Activity
Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine)
Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Phospholipid Metabolic Process
Phosphatidic Acid Biosynthetic Process
Phosphatidylserine Metabolic Process
Axon Guidance
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Lipid Storage
Arachidonic Acid Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Prostaglandin Secretion
Low-density Lipoprotein Particle Remodeling
Phosphatidylcholine Catabolic Process
Phosphatidylglycerol Acyl-chain Remodeling
Phosphatidylinositol Acyl-chain Remodeling
Phosphatidylserine Acyl-chain Remodeling
Phosphatidylcholine Acyl-chain Remodeling
Phosphatidylethanolamine Acyl-chain Remodeling
Cholesterol Homeostasis
Regulation Of Macrophage Activation
Negative Regulation Of DNA-binding Transcription Factor Activity
Phosphatidylethanolamine Metabolic Process
Phosphatidylcholine Metabolic Process
Phosphatidylglycerol Metabolic Process
Phosphatidic Acid Metabolic Process
Arachidonic Acid Secretion
Defense Response To Virus
Lysophospholipid Transport
Platelet Activating Factor Catabolic Process
Positive Regulation Of Arachidonic Acid Secretion
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Acrosome Reaction
Regulation Of Transcription By RNA Polymerase II
Visual Perception
Sensory Perception Of Sound
Vestibulocochlear Nerve Development
Retinal Ganglion Cell Axon Guidance
Inner Ear Morphogenesis
Inner Ear Auditory Receptor Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Axon Extension
Neuromuscular Process Controlling Balance
Neuron Apoptotic Process
Pathways
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Drugs
Varespladib methyl
Crotalus adamanteus antivenin
Agkistrodon piscivorus antivenin
Diseases
Deafness, autosomal dominant
GWAS
Cholesteryl ester levels (
31551469
)
Glycerophospholipid levels (
26068415
)
PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia (
30450575
)
Response to cognitive-behavioural therapy in anxiety disorder (
31123309
)
Interacting Genes
49 interacting genes:
AGXT
AQP1
ARID5A
ATXN1
BAG3
BEX2
C1orf94
CATSPER1
CCDC120
CREB5
CYSRT1
FAM222B
FOXH1
GATA5
GNE
HGS
HOXC8
HR
HSF4
INCA1
KPRP
KRTAP11-1
KRTAP26-1
LCE1A
LCE1C
LCE2A
LCE2B
LCE2D
MAL
MAPKBP1
MGAT5B
MYO10
NOXA1
NTAQ1
OTX1
PITX1
PLA2R1
POU4F3
PPP1R32
ROR2
SNRPC
SPAG8
STK16
TBX6
TFG
TLX3
VGLL3
VPS37C
ZC3H10
7 interacting genes:
AURKA
DUSP21
GOLGA2
KRT31
KRTAP6-3
NHLRC4
PLA2G10
Entrez ID
8399
5459
HPRD ID
04674
03911
Ensembl ID
ENSG00000069764
ENSG00000091010
Uniprot IDs
O15496
Q15319
PDB IDs
1LE6
1LE7
4UY1
5G3M
5OW8
5OWC
6G5J
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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