PLA2G10 and VPS37C

Data Source:
BioGRID (two hybrid)

		PLA2G10	VPS37C
Description		phospholipase A2 group X	VPS37C subunit of ESCRT-I
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome	ESCRT I Complex Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle Host Cell Extracellular Exosome
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Protein Binding Calcium-dependent Protein Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylserine Metabolic Process Axon Guidance Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Arachidonic Acid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Macrophage Activation Negative Regulation Of DNA-binding Transcription Factor Activity Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonic Acid Secretion Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cholesterol Efflux Positive Regulation Of Acrosome Reaction	Protein Targeting To Membrane Protein Targeting To Vacuole Endosomal Transport Macroautophagy Viral Life Cycle Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Intracellular Transport Of Virus
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs		Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
Diseases
GWAS		Cholesteryl ester levels ( 31551469) Glycerophospholipid levels ( 26068415)	Periventricular white matter hyperintensities ( 32517579) Rheumatoid arthritis ( 23143596)
Interacting Genes		49 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE HGS HOXC8 HR HSF4 INCA1 KPRP KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE2A LCE2B LCE2D MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 POU4F3 PPP1R32 ROR2 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10	102 interacting genes: AARD ABHD11 ABI2 APP ASCL3 BAG4 BIRC7 C1orf94 CBFA2T3 CEP55 CRX DAZAP2 DCTN3 DDIT3 DYDC1 EYA2 FAM168A FAM168B FCHSD2 FOXI1 FUBP1 GOLGA2 GPS2 GRB2 HAUS1 HELT HGS HNRNPF HNRNPUL1 HYI ILF3 KLF1 KRT27 KRT33B KRTAP15-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LAGE3 LASP1 MAPK1IP1L METTL27 NTAQ1 NUP54 NUTM2F P4HA3 PAX9 PDCD6 PDCD6IP PEF1 PKNOX1 PKNOX2 PLA2G10 PLEKHG4 PLSCR1 POLR2J POLR2J3 POU2AF1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 RAMAC RBPMS RBPMS2 RFX6 RIBC1 RINT1 RPRD1B RUNX1 SH3GL1 SH3RF1 SH3RF2 SORBS2 SORBS3 SPAG8 STAM2 STH TACC3 TFAP2D TFG TFIP11 TIAL1 TLE5 TSC1 TSG101 UBAP2 UBC UFSP1 VPS28 WWOX WWP2 XIAP YTHDF1 ZMAT5 ZMYND12 ZNF34
Entrez ID		8399	55048
HPRD ID		04674	15652
Ensembl ID		ENSG00000069764	ENSG00000167987
Uniprot IDs		O15496	A5D8V6
PDB IDs		1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J
Enriched GO Terms of Interacting Partners?
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