PLA2G10 and GATA5

Data Source:
BioGRID (two hybrid)

		PLA2G10	GATA5
Description		phospholipase A2 group X	GATA binding protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome	Chromatin Nucleus Nucleoplasm
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylserine Metabolic Process Axon Guidance Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Arachidonic Acid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Macrophage Activation Negative Regulation Of DNA-binding Transcription Factor Activity Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonic Acid Secretion Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cholesterol Efflux Positive Regulation Of Acrosome Reaction	Aortic Valve Morphogenesis Endocardial Cushion Fusion Regulation Of Transcription By RNA Polymerase II Blood Coagulation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Notch Signaling Pathway Involved In Heart Induction Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Tissue Development Intestinal Epithelial Cell Differentiation Positive Regulation Of Cardiac Endothelial To Mesenchymal Transition Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Factors involved in megakaryocyte development and platelet production
Drugs		Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
Diseases
GWAS		Cholesteryl ester levels ( 31551469) Glycerophospholipid levels ( 26068415)	Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Central serous retinopathy ( 31872073) Chronic central serous retinopathy ( 30073298) Hematocrit ( 32888494) Hemoglobin ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		49 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE HGS HOXC8 HR HSF4 INCA1 KPRP KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE2A LCE2B LCE2D MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 POU4F3 PPP1R32 ROR2 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10	10 interacting genes: ARID5A CYSRT1 EP300 HNF1A HPCA HPCAL1 KLF2 MAGED1 PLA2G10 PPARG
Entrez ID		8399	140628
HPRD ID		04674	17029
Ensembl ID		ENSG00000069764	ENSG00000130700
Uniprot IDs		O15496	Q9BWX5
PDB IDs		1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J
Enriched GO Terms of Interacting Partners?
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