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OTX1 and GRN
Data Source:
BioGRID
(two hybrid, two hybrid, two hybrid)
OTX1
GRN
Description
orthodenticle homeobox 1
granulin precursor
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Extracellular Region
Extracellular Space
Lysosome
Lysosomal Membrane
Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Membrane
Azurophil Granule Lumen
Extracellular Exosome
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Sequence-specific Double-stranded DNA Binding
RNA Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Chaperone Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Anterior/posterior Pattern Specification
Metencephalon Development
Midbrain Development
Inner Ear Morphogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Diencephalon Morphogenesis
Astrocyte Activation Involved In Immune Response
Microglial Cell Activation Involved In Immune Response
Lysosome Organization
Lysosomal Transport
Lysosomal Lumen Acidification
Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cell Migration
Neutrophil Degranulation
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Axon Regeneration
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Protein Stabilization
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Defense Response To Bacterium
Negative Regulation Of Neutrophil Activation
Positive Regulation Of Protein Folding
Negative Regulation Of Microglial Cell Activation
Positive Regulation Of Aspartic-type Peptidase Activity
Positive Regulation Of Lysosome Organization
Pathways
Neutrophil degranulation
Drugs
Diseases
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS
Fruit consumption (
32066663
)
Neurociticism (
29500382
)
Regular attendance at a religious group (
29970889
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Blood protein levels (
30072576
29875488
)
Brain morphology (MOSTest) (
32665545
)
Intracranial volume (
22504418
)
Progranulin levels (
29186428
)
Subcortical brain region volumes (
25607358
)
Interacting Genes
144 interacting genes:
ADAM12
ADAMTSL4
ALPP
ANKRD10
ARHGEF17
ARID5A
ATG9B
BHLHB9
C10orf55
C11orf1
CCN4
CERCAM
CH25H
CHIC2
CHRD
CHRDL2
COL8A1
COMP
CTAG2
CYSRT1
DPY30
EFEMP2
ETFDH
FAM168B
FAM72B
FBLN2
FBLN5
FHL5
GEMIN8P4
GPRIN2
GRN
HIVEP1
INTS11
KCNK16
KLHL26
KPRP
KRT31
KRT35
KRT37
KRT81
KRT85
KRTAP1-1
KRTAP1-3
KRTAP1-5
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP13-1
KRTAP13-2
KRTAP13-3
KRTAP17-1
KRTAP19-2
KRTAP19-7
KRTAP2-3
KRTAP2-4
KRTAP22-1
KRTAP26-1
KRTAP3-1
KRTAP3-2
KRTAP3-3
KRTAP4-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP4-7
KRTAP5-11
KRTAP5-3
KRTAP5-6
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LASP1
LCE1B
LCE1C
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE4A
LGALS13
M1AP
MDFI
MGAT5B
MIIP
MTNR1B
NBPF19
NDUFAF6
NECTIN3
NHLRC4
NOTCH2NLA
OXER1
PCSK5
PLA2G10
PLEKHG4
PLSCR2
POU2AF1
PRICKLE4
PRR13
PRR22
RBPMS
RGS17
RGS19
RGS20
RNF144B
RTN4R
SLC15A2
SMARCC1
SPRY1
SPRY2
SPRY4
SPRYD7
TEX37
TLE4
TNS2
TRIM42
TRIP6
TSPAN4
UBAP2
USP54
VWC2
VWC2L
WWOX
YPEL3
ZBTB42
ZNF330
ZNF34
79 interacting genes:
ARFGAP1
ATN1
ATXN7
C22orf39
C4orf17
CACNA1A
CCDC33
CCNG1
CCNT1
CDK9
CLPP
CRCT1
CRKL
CRY1
CXCL5
CYSRT1
DLK1
DLX2
DMRT3
ECM1
ELANE
FAM131C
FAM76B
FANCL
FRAT1
GFI1B
GLRX3
GNE
HK3
HOXA1
HSPG2
KRT18
KRT34
KRTAP1-1
KRTAP1-5
KRTAP10-7
KRTAP10-8
KRTAP11-1
KRTAP12-1
KRTAP13-2
KRTAP15-1
KRTAP26-1
KRTAP5-9
KRTAP6-1
KRTAP6-2
LCE1A
LCE1D
LCE1E
LCE2B
LCE2D
LCE3C
LCE3E
LCE4A
MEOX2
NLK
NUFIP2
OTX1
P4HB
PIK3R2
PLLP
POT1
POU4F2
PRKAB2
PTPMT1
RAC1
SGTA
SLC13A1
SLPI
SMAD9
SMCP
SPRY2
TAT
TGM2
TLE5
TOP3B
TSPAN4
UTP23
VASN
YY1
Entrez ID
5013
2896
HPRD ID
08964
00733
Ensembl ID
ENSG00000115507
ENSG00000030582
Uniprot IDs
P32242
P28799
PDB IDs
1G26
2JYE
2JYT
2JYU
2JYV
6NUG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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