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OTX1 and FBLN5
Data Source:
BioGRID
(two hybrid)
OTX1
FBLN5
Description
orthodenticle homeobox 1
fibulin 5
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Extracellular Region
Extracellular Space
Extracellular Matrix
Collagen-containing Extracellular Matrix
Extracellular Exosome
Elastic Fiber
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Sequence-specific Double-stranded DNA Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Protein C-terminus Binding
Extracellular Matrix Constituent Conferring Elasticity
Protein Homodimerization Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Anterior/posterior Pattern Specification
Metencephalon Development
Midbrain Development
Inner Ear Morphogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Diencephalon Morphogenesis
Cell-matrix Adhesion
Extracellular Matrix Organization
Protein Localization To Cell Surface
Secretion
Elastic Fiber Assembly
Regulation Of Removal Of Superoxide Radicals
Pathways
Elastic fibre formation
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Drugs
Diseases
Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS
Fruit consumption (
32066663
)
Neurociticism (
29500382
)
Regular attendance at a religious group (
29970889
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Diastolic blood pressure (
30578418
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction (
31806883
)
Heel bone mineral density (
30598549
)
Height (
25429064
31562340
18391951
)
Optic disc size (
31809533
)
Pulse pressure (
27841878
30578418
)
Waist circumference adjusted for body mass index (
28552196
)
Interacting Genes
144 interacting genes:
ADAM12
ADAMTSL4
ALPP
ANKRD10
ARHGEF17
ARID5A
ATG9B
BHLHB9
C10orf55
C11orf1
CCN4
CERCAM
CH25H
CHIC2
CHRD
CHRDL2
COL8A1
COMP
CTAG2
CYSRT1
DPY30
EFEMP2
ETFDH
FAM168B
FAM72B
FBLN2
FBLN5
FHL5
GEMIN8P4
GPRIN2
GRN
HIVEP1
INTS11
KCNK16
KLHL26
KPRP
KRT31
KRT35
KRT37
KRT81
KRT85
KRTAP1-1
KRTAP1-3
KRTAP1-5
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP12-4
KRTAP13-1
KRTAP13-2
KRTAP13-3
KRTAP17-1
KRTAP19-2
KRTAP19-7
KRTAP2-3
KRTAP2-4
KRTAP22-1
KRTAP26-1
KRTAP3-1
KRTAP3-2
KRTAP3-3
KRTAP4-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP4-7
KRTAP5-11
KRTAP5-3
KRTAP5-6
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LASP1
LCE1B
LCE1C
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE4A
LGALS13
M1AP
MDFI
MGAT5B
MIIP
MTNR1B
NBPF19
NDUFAF6
NECTIN3
NHLRC4
NOTCH2NLA
OXER1
PCSK5
PLA2G10
PLEKHG4
PLSCR2
POU2AF1
PRICKLE4
PRR13
PRR22
RBPMS
RGS17
RGS19
RGS20
RNF144B
RTN4R
SLC15A2
SMARCC1
SPRY1
SPRY2
SPRY4
SPRYD7
TEX37
TLE4
TNS2
TRIM42
TRIP6
TSPAN4
UBAP2
USP54
VWC2
VWC2L
WWOX
YPEL3
ZBTB42
ZNF330
ZNF34
12 interacting genes:
ATN1
GFI1B
LOXL1
LPA
MEOX2
NUFIP2
OTX1
PAXIP1
PRNP
SOD3
TOP3B
TRIP13
Entrez ID
5013
10516
HPRD ID
08964
05204
Ensembl ID
ENSG00000115507
ENSG00000140092
Uniprot IDs
P32242
A0A024R6G3
Q9UBX5
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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