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LMNA and DERL1
Data Source:
BioGRID
(two hybrid)
LMNA
DERL1
Description
lamin A/C
derlin 1
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nuclear Lamina
Nucleoplasm
Cytosol
Intermediate Filament
Nuclear Matrix
Nuclear Body
Nuclear Speck
Nuclear Membrane
Site Of Double-strand Break
Hrd1p Ubiquitin Ligase ERAD-L Complex
Early Endosome
Late Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Derlin-1-VIMP Complex
Derlin-1 Retrotranslocation Complex
Endoplasmic Reticulum Quality Control Compartment
Molecular Function
Protein Binding
Protease Binding
Signal Recognition Particle Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
MHC Class I Protein Binding
Identical Protein Binding
Protein-containing Complex Binding
ATPase Binding
Misfolded Protein Binding
Ubiquitin-specific Protease Binding
Biological Process
Mitotic Nuclear Envelope Reassembly
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Migration
Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity
Protein Localization To Nucleus
IRE1-mediated Unfolded Protein Response
Cellular Response To Hypoxia
Positive Regulation Of Cell Aging
Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
DNA Double-strand Break Attachment To Nuclear Envelope
Protein Folding
Response To Unfolded Protein
Viral Process
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Positive Regulation Of Protein Binding
ERAD Pathway
Establishment Of Protein Localization
Transmembrane Transport
ER-associated Misfolded Protein Catabolic Process
Pathways
XBP1(S) activates chaperone genes
Signaling by BRAF and RAF fusions
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Defective CFTR causes cystic fibrosis
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
Restrictive dermopathy
Emery-Dreifuss muscular dystrophy
Dilated cardiomyopathy (DCM)
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
Mandibuloacral dysplasia
Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
Limb-girdle muscular dystrophy (LGMD)
Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
Hutchinson-Gilford progeria syndrome
GWAS
Birth weight (
31043758
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Ischemic heart disease in rheumatoid arthritis (
30251476
)
Lung cancer in ever smokers (
28604730
)
Neutrophil count (
32888494
)
Ovarian cancer (
30557369
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Urate levels (
31578528
)
White blood cell count (
32888494
)
Mean reticulocyte volume (
32888494
)
Metabolite levels (
23823483
)
Interacting Genes
381 interacting genes:
ABCA9
ACOT7
ACTB
ADAM33
ADGRE2
ADGRG7
AGTRAP
AIG1
AKTIP
ALG3
ALG8
ALOX12
ALOX12B
ANKRD20A5P
ANXA6
AOC3
APOA2
APOD
APOL2
AQP1
AQP10
AQP3
ARHGEF16
ARL6IP1
ASGR1
ATP6V0C
BCL2L2
BNIP2
BNIP3
BNIP3L
BRICD5
BTN2A2
BYSL
C11orf24
C1QTNF1
C20orf141
C3orf52
C4orf3
C5
CACNG1
CASP1
CASP6
CCDC120
CCNG1
CD52
CD72
CD81
CDK1
CDS2
CENPP
CETN3
CFHR5
CHST1
CLCA4
CLCN7
CLDN10
CLDND2
CLEC1A
CLEC4A
CLK1
CLN6
CMTM3
CMTM5
CMTM7
CNIH3
COL8A2
COX14
CREB3
CRY2
CSGALNACT2
CTSA
CWF19L2
CXCL14
CXCL16
CYB561
CYB561D2
CYB5B
CYBC1
CYBRD1
DBNDD2
DDX24
DDX43
DEFB127
DERL1
DERL2
DNAJC30
DUS3L
DUSP13
EDDM3B
EGF
EIF3G
ELOA
EMD
ENTPD3
ERG28
F2RL1
FA2H
FAIM
FAM161A
FAM3C
FAM9B
FATE1
FAXDC2
FBXO7
FCER1A
FCER1G
FDFT1
FETUB
FLNA
FOS
FXYD3
FXYD6
GALNT2
GIN1
GJB2
GJB5
GOLGA2P10
GOLT1B
GOSR2
GPR108
GPR25
GRM2
GZMA
GZMB
HACD1
HCK
HMOX1
HMOX2
IFFO1
IFIT2
IGFBP5
INSIG2
ITGAM
ITM2B
IZUMO2
JAGN1
KASH5
KAT5
KCNK1
KCNK13
KIF12
KPNA6
KRT6A
KRTAP10-3
KRTAP10-7
LAMB1
LAT
LCP2
LEPROTL1
LHFPL5
LIMS2
LINC01587
LMBR1
LMNB1
LMNB2
LPAR3
LRP10
LVRN
MAL
MALL
MAPRE2
MARVELD1
MATR3
MCM5
MEOX1
MFAP1
MFSD5
MGLL
MGST3
MIP
MLIP
MMD2
MORF4L1
MRPS26
MS4A1
MTHFD2
MUTYH
MYADM
NAB2
NALCN
NARF
NAT8
NEU1
NINJ2
NIPAL3
NKG7
NOD2
NTAQ1
ORMDL1
ORMDL3
OSBPL8
OSTCP1
OSTF1
PAQR5
PARPBP
PCBP1
PCGF2
PCNA
PELI1
PERM1
PIAS2
PIK3R2
PKD2
PLLP
PLP1
PLP2
PLPP4
PMP22
PNKP
PNLIPRP1
PRELID3A
PRKCA
PRNP
PTPN9
PYGM
RABAC1
RANBP9
RB1
RBBP4
REEP6
RGS18
RHAG
RMDN2
RNF123
RPRM
RTN1
RTN3
RTN4
RUSF1
SACM1L
SBDS
SCARA3
SCARB2
SEC22A
SEC22B
SELENOK
SENP2
SERP1
SERP2
SERPINE1
SFT2D2
SFTPC
SGMS2
SH3RF2
SIAH1
SLC13A3
SLC1A1
SLC2A5
SLC30A2
SLC30A3
SLC30A8
SLC35A1
SLC35A4
SLC35B2
SLC35B4
SLC38A7
SLC41A2
SLC7A1
SLN
SLU7
SMAD1
SMAD3
SMCO4
SMIM11A
SMURF1
SMURF2
SNORC
SPANXC
SPANXD
SPG21
SPN
SREBF1
SRPK2
STAC
STAC2
STARD3
STX12
STX3
STX4
STX5
STX6
STX7
STX8
SUMO2
SUMO4
SVIL
SYCE1
SYNE1
SYNGR1
SYPL1
SYT6
TAP1
TCEA2
TCEANC
TDO2
TFRC
THBD
TM4SF20
TMEM107
TMEM109
TMEM11
TMEM120B
TMEM128
TMEM140
TMEM14A
TMEM14B
TMEM14C
TMEM199
TMEM201
TMEM203
TMEM208
TMEM218
TMEM222
TMEM230
TMEM234
TMEM243
TMEM267
TMEM41A
TMEM42
TMEM43
TMEM51
TMEM54
TMEM60
TMEM65
TMEM74
TMEM86A
TMPO
TMPRSS4
TNF
TNFRSF10C
TNFSF12
TNMD
TOR1A
TOR1AIP1
TRAM1L1
TRIM26
TRIM39
TSGA10
TSNARE1
TSPAN2
TSPAN33
TSPAN7
UBE2I
UBE2Q1
UBQLNL
UCHL5
UNC13D
UNC45A
UNC50
UPK1B
URB2
USE1
USP2
USP20
VAMP1
VAMP2
VAMP3
VAMP5
VKORC1
VMP1
VSTM1
VTI1B
WFDC2
YIPF1
YIPF6
YWHAQ
ZC2HC1C
ZDHHC15
ZDHHC24
ZMYM6
ZNF138
ZNF239
ZNF25
ZNF3
ZNF439
ZNF440
ZNF490
ZNF564
ZNF569
ZNF69
ZSCAN12
33 interacting genes:
ABHD4
AMFR
APP
AQP6
CFTR
CIAO2A
FCRL4
FFAR2
GAD2
HLA-A
KASH5
LMNA
LNX1
MELTF
REEP4
RETREG3
RHO
SCN3B
SELENOS
SLC10A1
SLC10A6
SLC30A8
SLC7A14
SLC7A8
TCF25
TEX44
TMED8
TMEM31
TMX2
TRIM32
UBE2J1
UBXN6
VCP
Entrez ID
4000
79139
HPRD ID
01035
12302
Ensembl ID
ENSG00000160789
ENSG00000136986
Uniprot IDs
A0A384MQX1
P02545
Q5TCI8
A0A024R9G3
E5RGY0
Q9BUN8
PDB IDs
1IFR
1IVT
1X8Y
2XV5
2YPT
3GEF
3V4Q
3V4W
3V5B
6GHD
6JLB
6RPR
6SNZ
6YF5
5GLF
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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