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LMNA and KRTAP10-7
Data Source:
BioGRID
(two hybrid)
LMNA
KRTAP10-7
Description
lamin A/C
keratin associated protein 10-7
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nuclear Lamina
Nucleoplasm
Cytosol
Intermediate Filament
Nuclear Matrix
Nuclear Body
Nuclear Speck
Nuclear Membrane
Site Of Double-strand Break
Cytosol
Keratin Filament
Molecular Function
Protein Binding
Protein Binding
Identical Protein Binding
Biological Process
Mitotic Nuclear Envelope Reassembly
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Migration
Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity
Protein Localization To Nucleus
IRE1-mediated Unfolded Protein Response
Cellular Response To Hypoxia
Positive Regulation Of Cell Aging
Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
DNA Double-strand Break Attachment To Nuclear Envelope
Keratinization
Pathways
XBP1(S) activates chaperone genes
Signaling by BRAF and RAF fusions
Keratinization
Drugs
Diseases
Restrictive dermopathy
Emery-Dreifuss muscular dystrophy
Dilated cardiomyopathy (DCM)
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
Mandibuloacral dysplasia
Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
Limb-girdle muscular dystrophy (LGMD)
Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
Hutchinson-Gilford progeria syndrome
GWAS
Birth weight (
31043758
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Ischemic heart disease in rheumatoid arthritis (
30251476
)
Lung cancer in ever smokers (
28604730
)
Neutrophil count (
32888494
)
Ovarian cancer (
30557369
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Urate levels (
31578528
)
White blood cell count (
32888494
)
Interacting Genes
381 interacting genes:
ABCA9
ACOT7
ACTB
ADAM33
ADGRE2
ADGRG7
AGTRAP
AIG1
AKTIP
ALG3
ALG8
ALOX12
ALOX12B
ANKRD20A5P
ANXA6
AOC3
APOA2
APOD
APOL2
AQP1
AQP10
AQP3
ARHGEF16
ARL6IP1
ASGR1
ATP6V0C
BCL2L2
BNIP2
BNIP3
BNIP3L
BRICD5
BTN2A2
BYSL
C11orf24
C1QTNF1
C20orf141
C3orf52
C4orf3
C5
CACNG1
CASP1
CASP6
CCDC120
CCNG1
CD52
CD72
CD81
CDK1
CDS2
CENPP
CETN3
CFHR5
CHST1
CLCA4
CLCN7
CLDN10
CLDND2
CLEC1A
CLEC4A
CLK1
CLN6
CMTM3
CMTM5
CMTM7
CNIH3
COL8A2
COX14
CREB3
CRY2
CSGALNACT2
CTSA
CWF19L2
CXCL14
CXCL16
CYB561
CYB561D2
CYB5B
CYBC1
CYBRD1
DBNDD2
DDX24
DDX43
DEFB127
DERL1
DERL2
DNAJC30
DUS3L
DUSP13
EDDM3B
EGF
EIF3G
ELOA
EMD
ENTPD3
ERG28
F2RL1
FA2H
FAIM
FAM161A
FAM3C
FAM9B
FATE1
FAXDC2
FBXO7
FCER1A
FCER1G
FDFT1
FETUB
FLNA
FOS
FXYD3
FXYD6
GALNT2
GIN1
GJB2
GJB5
GOLGA2P10
GOLT1B
GOSR2
GPR108
GPR25
GRM2
GZMA
GZMB
HACD1
HCK
HMOX1
HMOX2
IFFO1
IFIT2
IGFBP5
INSIG2
ITGAM
ITM2B
IZUMO2
JAGN1
KASH5
KAT5
KCNK1
KCNK13
KIF12
KPNA6
KRT6A
KRTAP10-3
KRTAP10-7
LAMB1
LAT
LCP2
LEPROTL1
LHFPL5
LIMS2
LINC01587
LMBR1
LMNB1
LMNB2
LPAR3
LRP10
LVRN
MAL
MALL
MAPRE2
MARVELD1
MATR3
MCM5
MEOX1
MFAP1
MFSD5
MGLL
MGST3
MIP
MLIP
MMD2
MORF4L1
MRPS26
MS4A1
MTHFD2
MUTYH
MYADM
NAB2
NALCN
NARF
NAT8
NEU1
NINJ2
NIPAL3
NKG7
NOD2
NTAQ1
ORMDL1
ORMDL3
OSBPL8
OSTCP1
OSTF1
PAQR5
PARPBP
PCBP1
PCGF2
PCNA
PELI1
PERM1
PIAS2
PIK3R2
PKD2
PLLP
PLP1
PLP2
PLPP4
PMP22
PNKP
PNLIPRP1
PRELID3A
PRKCA
PRNP
PTPN9
PYGM
RABAC1
RANBP9
RB1
RBBP4
REEP6
RGS18
RHAG
RMDN2
RNF123
RPRM
RTN1
RTN3
RTN4
RUSF1
SACM1L
SBDS
SCARA3
SCARB2
SEC22A
SEC22B
SELENOK
SENP2
SERP1
SERP2
SERPINE1
SFT2D2
SFTPC
SGMS2
SH3RF2
SIAH1
SLC13A3
SLC1A1
SLC2A5
SLC30A2
SLC30A3
SLC30A8
SLC35A1
SLC35A4
SLC35B2
SLC35B4
SLC38A7
SLC41A2
SLC7A1
SLN
SLU7
SMAD1
SMAD3
SMCO4
SMIM11A
SMURF1
SMURF2
SNORC
SPANXC
SPANXD
SPG21
SPN
SREBF1
SRPK2
STAC
STAC2
STARD3
STX12
STX3
STX4
STX5
STX6
STX7
STX8
SUMO2
SUMO4
SVIL
SYCE1
SYNE1
SYNGR1
SYPL1
SYT6
TAP1
TCEA2
TCEANC
TDO2
TFRC
THBD
TM4SF20
TMEM107
TMEM109
TMEM11
TMEM120B
TMEM128
TMEM140
TMEM14A
TMEM14B
TMEM14C
TMEM199
TMEM201
TMEM203
TMEM208
TMEM218
TMEM222
TMEM230
TMEM234
TMEM243
TMEM267
TMEM41A
TMEM42
TMEM43
TMEM51
TMEM54
TMEM60
TMEM65
TMEM74
TMEM86A
TMPO
TMPRSS4
TNF
TNFRSF10C
TNFSF12
TNMD
TOR1A
TOR1AIP1
TRAM1L1
TRIM26
TRIM39
TSGA10
TSNARE1
TSPAN2
TSPAN33
TSPAN7
UBE2I
UBE2Q1
UBQLNL
UCHL5
UNC13D
UNC45A
UNC50
UPK1B
URB2
USE1
USP2
USP20
VAMP1
VAMP2
VAMP3
VAMP5
VKORC1
VMP1
VSTM1
VTI1B
WFDC2
YIPF1
YIPF6
YWHAQ
ZC2HC1C
ZDHHC15
ZDHHC24
ZMYM6
ZNF138
ZNF239
ZNF25
ZNF3
ZNF439
ZNF440
ZNF490
ZNF564
ZNF569
ZNF69
ZSCAN12
282 interacting genes:
AEN
ALDH3B1
ANKRD36BP1
AP1M1
APP
AQP1
AVPI1
B4GALT7
BAHD1
BCL6B
BMP7
BRME1
BUD31
BYSL
C8orf33
CARHSP1
CATIP
CBX2
CCDC185
CCDC26
CCNG1
CDCA7L
CHIC2
CHRD
CHRNG
CLK1
CLK4
CNNM3
COL8A1
CRCT1
CREB5
CRY2
CSNK1G1
CSNK1G2
CTNNBIP1
CTRC
CXCL16
CYSRT1
DAAM2
DERL2
DHX57
DMRT3
DOCK2
E2F6
E4F1
EHHADH
FADS6
FAM124B
FAM161A
FAM27E3
FAM74A4
FAM76B
FARS2
GABARAPL1
GABARAPL2
GEM
GLIDR
GLP1R
GNE
GOLGA8EP
GRN
GSTP1
GUCD1
HBZ
HCK
HHEX
HOXA1
HOXC8
HPCAL1
HSBP1
HSD3B7
IGSF8
ING5
INPP5D
IQUB
ITGB4
ITGB5
KLHL38
KRT20
KRT83
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP12-3
KRTAP26-1
KRTAP4-2
KRTAP4-5
KRTAP5-11
KRTAP5-2
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-8
LCE1A
LCE1B
LCE1D
LCE1F
LCE2A
LCE2B
LCE2C
LCE3A
LCE3B
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LIMS2
LINC00242
LMNA
LMO2
LRCH4
MAPKBP1
MCM5
MCRS1
MOBP
MRGBP
MXD3
MXI1
MYPOP
NAA10
NAXD
NECTIN2
NECTIN3
NKD1
NOL12
NOTCH2NLA
NPBWR2
NPDC1
NTAQ1
NUBP2
NUDCD3
NUFIP2
OTX1
P2RY6
PCED1A
PCSK5
PDE9A
PDIA5
PDLIM5
PFKL
PGAP6
PHLDA1
PIN1
POLL
POM121L8P
PPARD
PRKAB2
PRM2
PRR13
PRR35
PTGDS
PTGER3
PTPMT1
PVR
R3HDM2
RNF175
RPF1
RPL11
RPL36AL
RPS28
RPUSD3
RSPO2
RTN4RL1
RWDD2B
SCNM1
SDCBP
SHFL
SLC23A1
SLC25A48
SLC6A20
SMCO4
SMCP
SPACA9
SPATA24
SPATA3
SPATA8
SPG7
SPRY1
SSX2IP
STAT3
STK16
SUV39H1
TAPBPL
TCEA2
TCEANC
TEDC2
TFAP2D
THAP1
THAP6
TLE5
TMA16
TNP2
TNS2
TOR1A
TREX1
TRIM42
TTPA
TULP3
TXNDC5
TYRO3
UCP2
UXT
VASN
VGLL3
VTI1B
WNT11
WT1
ZBTB24
ZBTB38
ZBTB48
ZBTB9
ZFP41
ZFYVE26
ZIM2
ZNF101
ZNF124
ZNF133
ZNF138
ZNF155
ZNF165
ZNF169
ZNF175
ZNF180
ZNF2
ZNF20
ZNF223
ZNF250
ZNF256
ZNF26
ZNF260
ZNF264
ZNF266
ZNF32
ZNF320
ZNF329
ZNF337
ZNF408
ZNF41
ZNF414
ZNF417
ZNF418
ZNF419
ZNF420
ZNF425
ZNF433
ZNF439
ZNF440
ZNF444
ZNF490
ZNF491
ZNF524
ZNF543
ZNF555
ZNF564
ZNF572
ZNF575
ZNF578
ZNF580
ZNF581
ZNF587
ZNF625
ZNF667
ZNF670
ZNF696
ZNF697
ZNF707
ZNF764
ZNF774
ZNF778
ZNF786
ZNF792
ZNF837
ZNF844
ZNF846
ZNHIT1
ZSCAN10
ZSCAN21
ZSCAN26
Entrez ID
4000
386675
HPRD ID
01035
11193
Ensembl ID
ENSG00000160789
ENSG00000272804
Uniprot IDs
A0A384MQX1
P02545
Q5TCI8
P60409
PDB IDs
1IFR
1IVT
1X8Y
2XV5
2YPT
3GEF
3V4Q
3V4W
3V5B
6GHD
6JLB
6RPR
6SNZ
6YF5
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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