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DERL1 and CFTR
Data Source:
HPRD
(in vivo)
DERL1
CFTR
Description
derlin 1
CF transmembrane conductance regulator
Image
GO Annotations
Cellular Component
Hrd1p Ubiquitin Ligase ERAD-L Complex
Early Endosome
Late Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Derlin-1-VIMP Complex
Derlin-1 Retrotranslocation Complex
Endoplasmic Reticulum Quality Control Compartment
Nucleus
Cytoplasm
Lysosomal Membrane
Early Endosome
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Integral Component Of Membrane
Apical Plasma Membrane
Golgi-associated Vesicle Membrane
Clathrin-coated Vesicle Membrane
Early Endosome Membrane
Protein-containing Complex
Chloride Channel Complex
Recycling Endosome
Recycling Endosome Membrane
Molecular Function
Protease Binding
Signal Recognition Particle Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
MHC Class I Protein Binding
Identical Protein Binding
Protein-containing Complex Binding
ATPase Binding
Misfolded Protein Binding
Ubiquitin-specific Protease Binding
Chloride Channel Activity
Intracellularly ATP-gated Chloride Channel Activity
Protein Binding
ATP Binding
Bicarbonate Transmembrane Transporter Activity
Chloride Transmembrane Transporter Activity
Isomerase Activity
ATPase Activity
Chloride Channel Regulator Activity
Chloride Channel Inhibitor Activity
Enzyme Binding
PDZ Domain Binding
ATPase-coupled Transmembrane Transporter Activity
Chaperone Binding
Sec61 Translocon Complex Binding
Biological Process
Protein Folding
Response To Unfolded Protein
Viral Process
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Positive Regulation Of Protein Binding
ERAD Pathway
Establishment Of Protein Localization
Transmembrane Transport
ER-associated Misfolded Protein Catabolic Process
Cholesterol Biosynthetic Process
Vesicle Docking Involved In Exocytosis
Bicarbonate Transport
Protein Deubiquitination
Cholesterol Transport
Response To Endoplasmic Reticulum Stress
Transepithelial Water Transport
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Positive Regulation Of Exocytosis
Sperm Capacitation
Multicellular Organismal Water Homeostasis
Intracellular PH Elevation
Transmembrane Transport
Membrane Hyperpolarization
Membrane Organization
Cellular Response To CAMP
Positive Regulation Of Cyclic Nucleotide-gated Ion Channel Activity
Chloride Transmembrane Transport
Positive Regulation Of Voltage-gated Chloride Channel Activity
Cellular Response To Forskolin
Pathways
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Defective CFTR causes cystic fibrosis
E3 ubiquitin ligases ubiquitinate target proteins
ABC-family proteins mediated transport
RHO GTPases regulate CFTR trafficking
Defective CFTR causes cystic fibrosis
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Aggrephagy
Drugs
ATP
Bumetanide
Glyburide
Ibuprofen
Colforsin
Phosphoaminophosphonic Acid-Adenylate Ester
Dexfosfoserine
Crofelemer
Lonidamine
Ivacaftor
Dexibuprofen
Lumacaftor
Tezacaftor
Elexacaftor
Diseases
Cystic fibrosis (CF)
Hereditary pancreatitis; Hereditary chronic pancreatitis
Congenital bilateral absence of vas deferens
GWAS
Mean reticulocyte volume (
32888494
)
Metabolite levels (
23823483
)
Barrett's esophagus or Esophageal adenocarcinoma (
27527254
)
Glaucoma (
30054594
)
Gout (
22179738
)
Response to methotrexate in juvenile idiopathic arthritis (
24709693
)
Response to platinum-based chemotherapy in non-small-cell lung cancer (
22872573
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
33 interacting genes:
ABHD4
AMFR
APP
AQP6
CFTR
CIAO2A
FCRL4
FFAR2
GAD2
HLA-A
KASH5
LMNA
LNX1
MELTF
REEP4
RETREG3
RHO
SCN3B
SELENOS
SLC10A1
SLC10A6
SLC30A8
SLC7A14
SLC7A8
TCF25
TEX44
TMED8
TMEM31
TMX2
TRIM32
UBE2J1
UBXN6
VCP
29 interacting genes:
CANX
CLCN3
DERL1
DNAJA1
DNAJC5
EZR
GOPC
HSP90AA1
MARCHF2
NHS
PDZD3
PDZK1
PPP2R1B
PRKAA1
PRKACA
PRKAR2A
PRKCA
PRKCE
PRKG1
RNF5
SLC4A7
SLC4A8
SLC9A3R1
SLC9A3R2
SLC9A6
SNAP23
STUB1
STX1A
UBE2I
Entrez ID
79139
1080
HPRD ID
12302
03883
Ensembl ID
ENSG00000136986
ENSG00000001626
Uniprot IDs
A0A024R9G3
E5RGY0
Q9BUN8
A0A024R730
P13569
PDB IDs
5GLF
1NBD
1XMI
1XMJ
2BBO
2BBS
2BBT
2LOB
2PZE
2PZF
2PZG
3GD7
3ISW
4WZ6
5D2D
5D3E
5D3F
5TF7
5TF8
5TFA
5TFB
5TFC
5TFD
5TFF
5TFG
5TFI
5TFJ
5TGK
5UAK
6GJQ
6GJS
6GJU
6GK4
6GKD
6HEP
6MSM
6O1V
6O2P
6UK1
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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