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LMNA and ZC2HC1C
Data Source:
BioGRID
(two hybrid)
LMNA
ZC2HC1C
Description
lamin A/C
zinc finger C2HC-type containing 1C
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nuclear Lamina
Nucleoplasm
Cytosol
Intermediate Filament
Nuclear Matrix
Nuclear Body
Nuclear Speck
Nuclear Membrane
Site Of Double-strand Break
Molecular Function
Protein Binding
Protein Binding
Metal Ion Binding
Biological Process
Mitotic Nuclear Envelope Reassembly
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Migration
Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity
Protein Localization To Nucleus
IRE1-mediated Unfolded Protein Response
Cellular Response To Hypoxia
Positive Regulation Of Cell Aging
Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
DNA Double-strand Break Attachment To Nuclear Envelope
Pathways
XBP1(S) activates chaperone genes
Signaling by BRAF and RAF fusions
Drugs
Diseases
Restrictive dermopathy
Emery-Dreifuss muscular dystrophy
Dilated cardiomyopathy (DCM)
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
Mandibuloacral dysplasia
Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
Limb-girdle muscular dystrophy (LGMD)
Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
Hutchinson-Gilford progeria syndrome
GWAS
Birth weight (
31043758
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Ischemic heart disease in rheumatoid arthritis (
30251476
)
Lung cancer in ever smokers (
28604730
)
Neutrophil count (
32888494
)
Ovarian cancer (
30557369
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Urate levels (
31578528
)
White blood cell count (
32888494
)
Neurociticism (
29500382
)
Refractive error (
32231278
)
Interacting Genes
381 interacting genes:
ABCA9
ACOT7
ACTB
ADAM33
ADGRE2
ADGRG7
AGTRAP
AIG1
AKTIP
ALG3
ALG8
ALOX12
ALOX12B
ANKRD20A5P
ANXA6
AOC3
APOA2
APOD
APOL2
AQP1
AQP10
AQP3
ARHGEF16
ARL6IP1
ASGR1
ATP6V0C
BCL2L2
BNIP2
BNIP3
BNIP3L
BRICD5
BTN2A2
BYSL
C11orf24
C1QTNF1
C20orf141
C3orf52
C4orf3
C5
CACNG1
CASP1
CASP6
CCDC120
CCNG1
CD52
CD72
CD81
CDK1
CDS2
CENPP
CETN3
CFHR5
CHST1
CLCA4
CLCN7
CLDN10
CLDND2
CLEC1A
CLEC4A
CLK1
CLN6
CMTM3
CMTM5
CMTM7
CNIH3
COL8A2
COX14
CREB3
CRY2
CSGALNACT2
CTSA
CWF19L2
CXCL14
CXCL16
CYB561
CYB561D2
CYB5B
CYBC1
CYBRD1
DBNDD2
DDX24
DDX43
DEFB127
DERL1
DERL2
DNAJC30
DUS3L
DUSP13
EDDM3B
EGF
EIF3G
ELOA
EMD
ENTPD3
ERG28
F2RL1
FA2H
FAIM
FAM161A
FAM3C
FAM9B
FATE1
FAXDC2
FBXO7
FCER1A
FCER1G
FDFT1
FETUB
FLNA
FOS
FXYD3
FXYD6
GALNT2
GIN1
GJB2
GJB5
GOLGA2P10
GOLT1B
GOSR2
GPR108
GPR25
GRM2
GZMA
GZMB
HACD1
HCK
HMOX1
HMOX2
IFFO1
IFIT2
IGFBP5
INSIG2
ITGAM
ITM2B
IZUMO2
JAGN1
KASH5
KAT5
KCNK1
KCNK13
KIF12
KPNA6
KRT6A
KRTAP10-3
KRTAP10-7
LAMB1
LAT
LCP2
LEPROTL1
LHFPL5
LIMS2
LINC01587
LMBR1
LMNB1
LMNB2
LPAR3
LRP10
LVRN
MAL
MALL
MAPRE2
MARVELD1
MATR3
MCM5
MEOX1
MFAP1
MFSD5
MGLL
MGST3
MIP
MLIP
MMD2
MORF4L1
MRPS26
MS4A1
MTHFD2
MUTYH
MYADM
NAB2
NALCN
NARF
NAT8
NEU1
NINJ2
NIPAL3
NKG7
NOD2
NTAQ1
ORMDL1
ORMDL3
OSBPL8
OSTCP1
OSTF1
PAQR5
PARPBP
PCBP1
PCGF2
PCNA
PELI1
PERM1
PIAS2
PIK3R2
PKD2
PLLP
PLP1
PLP2
PLPP4
PMP22
PNKP
PNLIPRP1
PRELID3A
PRKCA
PRNP
PTPN9
PYGM
RABAC1
RANBP9
RB1
RBBP4
REEP6
RGS18
RHAG
RMDN2
RNF123
RPRM
RTN1
RTN3
RTN4
RUSF1
SACM1L
SBDS
SCARA3
SCARB2
SEC22A
SEC22B
SELENOK
SENP2
SERP1
SERP2
SERPINE1
SFT2D2
SFTPC
SGMS2
SH3RF2
SIAH1
SLC13A3
SLC1A1
SLC2A5
SLC30A2
SLC30A3
SLC30A8
SLC35A1
SLC35A4
SLC35B2
SLC35B4
SLC38A7
SLC41A2
SLC7A1
SLN
SLU7
SMAD1
SMAD3
SMCO4
SMIM11A
SMURF1
SMURF2
SNORC
SPANXC
SPANXD
SPG21
SPN
SREBF1
SRPK2
STAC
STAC2
STARD3
STX12
STX3
STX4
STX5
STX6
STX7
STX8
SUMO2
SUMO4
SVIL
SYCE1
SYNE1
SYNGR1
SYPL1
SYT6
TAP1
TCEA2
TCEANC
TDO2
TFRC
THBD
TM4SF20
TMEM107
TMEM109
TMEM11
TMEM120B
TMEM128
TMEM140
TMEM14A
TMEM14B
TMEM14C
TMEM199
TMEM201
TMEM203
TMEM208
TMEM218
TMEM222
TMEM230
TMEM234
TMEM243
TMEM267
TMEM41A
TMEM42
TMEM43
TMEM51
TMEM54
TMEM60
TMEM65
TMEM74
TMEM86A
TMPO
TMPRSS4
TNF
TNFRSF10C
TNFSF12
TNMD
TOR1A
TOR1AIP1
TRAM1L1
TRIM26
TRIM39
TSGA10
TSNARE1
TSPAN2
TSPAN33
TSPAN7
UBE2I
UBE2Q1
UBQLNL
UCHL5
UNC13D
UNC45A
UNC50
UPK1B
URB2
USE1
USP2
USP20
VAMP1
VAMP2
VAMP3
VAMP5
VKORC1
VMP1
VSTM1
VTI1B
WFDC2
YIPF1
YIPF6
YWHAQ
ZC2HC1C
ZDHHC15
ZDHHC24
ZMYM6
ZNF138
ZNF239
ZNF25
ZNF3
ZNF439
ZNF440
ZNF490
ZNF564
ZNF569
ZNF69
ZSCAN12
80 interacting genes:
ACTN2
ANKS1A
ARMC7
BANP
BICD2
BYSL
C19orf54
CABP5
CALCOCO2
CARD9
CBY2
CCDC102B
CCDC136
CCDC57
CCDC85B
CCDC88B
CIB3
CLIC3
CRACR2A
DDX6
EMILIN1
ENKD1
FAM90A1
FBXO7
FGFR1OP2
FSD2
GFAP
GOLGA1
GOLGA2
GOLGA6A
GPRASP2
HOOK2
HSF2BP
KASH5
KAT5
KATNBL1
KIF9
KRT15
KRT20
KRT40
LMNA
LMNB2
LZTS2
MAPK9
MAPRE3
MID2
MTUS2
NCKIPSD
NDEL1
NDOR1
NEK6
NOXA1
NTAQ1
OSGIN1
PFDN5
PIBF1
PNMA1
POLR1C
PRKAB2
PSTPIP1
RABGEF1
RAD51D
RINT1
SFN
SIKE1
SMARCD1
SORBS3
SPAG5
TFIP11
TNPO2
TRAF1
TRAF2
TRIM23
TRIM27
TRIM55
TRIM63
UBASH3A
VPS52
ZNF655
ZNF76
Entrez ID
4000
79696
HPRD ID
01035
16607
Ensembl ID
ENSG00000160789
ENSG00000119703
Uniprot IDs
A0A384MQX1
P02545
Q5TCI8
A0A024R6E6
H0YE08
J3KMY6
Q53FD0
PDB IDs
1IFR
1IVT
1X8Y
2XV5
2YPT
3GEF
3V4Q
3V4W
3V5B
6GHD
6JLB
6RPR
6SNZ
6YF5
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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