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DERL1 and GAD2
Data Source:
BioGRID
(two hybrid)
DERL1
GAD2
Description
derlin 1
glutamate decarboxylase 2
Image
GO Annotations
Cellular Component
Hrd1p Ubiquitin Ligase ERAD-L Complex
Early Endosome
Late Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Derlin-1-VIMP Complex
Derlin-1 Retrotranslocation Complex
Endoplasmic Reticulum Quality Control Compartment
Golgi Membrane
Cytosol
Plasma Membrane
Axon
Synaptic Vesicle Membrane
Anchored Component Of Membrane
Presynaptic Membrane
Perinuclear Region Of Cytoplasm
Inhibitory Synapse
Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
Molecular Function
Protease Binding
Signal Recognition Particle Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
MHC Class I Protein Binding
Identical Protein Binding
Protein-containing Complex Binding
ATPase Binding
Misfolded Protein Binding
Ubiquitin-specific Protease Binding
Glutamate Decarboxylase Activity
Protein Binding
Glutamate Binding
Pyridoxal Phosphate Binding
Protein-containing Complex Binding
Biological Process
Protein Folding
Response To Unfolded Protein
Viral Process
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Positive Regulation Of Protein Binding
ERAD Pathway
Establishment Of Protein Localization
Transmembrane Transport
ER-associated Misfolded Protein Catabolic Process
Glutamate Decarboxylation To Succinate
Chemical Synaptic Transmission
Neurotransmitter Secretion
Neurotransmitter Biosynthetic Process
Response To Drug
Pathways
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Defective CFTR causes cystic fibrosis
E3 ubiquitin ligases ubiquitinate target proteins
GABA synthesis
GABA synthesis, release, reuptake and degradation
MECP2 regulates transcription of genes involved in GABA signaling
Drugs
Pyridoxal phosphate
Glutamic acid
Diseases
GWAS
Mean reticulocyte volume (
32888494
)
Metabolite levels (
23823483
)
Lean body mass (
28552196
)
Interacting Genes
33 interacting genes:
ABHD4
AMFR
APP
AQP6
CFTR
CIAO2A
FCRL4
FFAR2
GAD2
HLA-A
KASH5
LMNA
LNX1
MELTF
REEP4
RETREG3
RHO
SCN3B
SELENOS
SLC10A1
SLC10A6
SLC30A8
SLC7A14
SLC7A8
TCF25
TEX44
TMED8
TMEM31
TMX2
TRIM32
UBE2J1
UBXN6
VCP
45 interacting genes:
ABHD5
AGTRAP
APOC2
APOC4
ARL13B
ARL6IP1
ARMC12
BSND
CACNG1
CMTM5
CPLX4
CYB561D1
DERL1
DERL3
DGAT2L6
DMKN
F10
FADS6
FAM114A2
FAM163A
GAD1
HIGD1C
LIME1
MAL2
MEST
MRM3
PBX3
PLIN3
PRKACA
PRKCE
RDH10
RHEX
RPRM
SCAMP1
SDR16C5
SEC22A
SMPD2
SPG21
SYCE2
SYNGR3
TMEM120B
TMEM128
TMEM159
TNFRSF10D
TSPAN33
Entrez ID
79139
2572
HPRD ID
12302
11817
Ensembl ID
ENSG00000136986
ENSG00000136750
Uniprot IDs
A0A024R9G3
E5RGY0
Q9BUN8
Q05329
Q5VZ30
PDB IDs
5GLF
1ES0
2OKK
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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