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LMNA and BYSL
Data Source:
BioGRID
(two hybrid)
LMNA
BYSL
Description
lamin A/C
bystin like
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nuclear Lamina
Nucleoplasm
Cytosol
Intermediate Filament
Nuclear Matrix
Nuclear Body
Nuclear Speck
Nuclear Membrane
Site Of Double-strand Break
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Cytosol
Membrane
Preribosome, Small Subunit Precursor
Intracellular Membrane-bounded Organelle
Apical Part Of Cell
Molecular Function
Protein Binding
RNA Binding
Protein Binding
SnoRNA Binding
Biological Process
Mitotic Nuclear Envelope Reassembly
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Migration
Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity
Protein Localization To Nucleus
IRE1-mediated Unfolded Protein Response
Cellular Response To Hypoxia
Positive Regulation Of Cell Aging
Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
DNA Double-strand Break Attachment To Nuclear Envelope
Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Trophectodermal Cell Differentiation
RRNA Processing
Cell Population Proliferation
Ribosome Biogenesis
Regulation Of Protein Localization To Nucleolus
Pathways
XBP1(S) activates chaperone genes
Signaling by BRAF and RAF fusions
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
Restrictive dermopathy
Emery-Dreifuss muscular dystrophy
Dilated cardiomyopathy (DCM)
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
Mandibuloacral dysplasia
Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
Limb-girdle muscular dystrophy (LGMD)
Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
Hutchinson-Gilford progeria syndrome
GWAS
Birth weight (
31043758
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Ischemic heart disease in rheumatoid arthritis (
30251476
)
Lung cancer in ever smokers (
28604730
)
Neutrophil count (
32888494
)
Ovarian cancer (
30557369
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Urate levels (
31578528
)
White blood cell count (
32888494
)
Hematological parameters (
19820697
)
Mean corpuscular hemoglobin (
20139978
19862010
)
Mean corpuscular volume (
23263863
20139978
19862010
)
Menarche (age at onset) (
27182965
25231870
)
Metabolite levels (
23823483
)
Monocyte percentage of white cells (
32888494
)
Red blood cell count (
20139978
)
Interacting Genes
381 interacting genes:
ABCA9
ACOT7
ACTB
ADAM33
ADGRE2
ADGRG7
AGTRAP
AIG1
AKTIP
ALG3
ALG8
ALOX12
ALOX12B
ANKRD20A5P
ANXA6
AOC3
APOA2
APOD
APOL2
AQP1
AQP10
AQP3
ARHGEF16
ARL6IP1
ASGR1
ATP6V0C
BCL2L2
BNIP2
BNIP3
BNIP3L
BRICD5
BTN2A2
BYSL
C11orf24
C1QTNF1
C20orf141
C3orf52
C4orf3
C5
CACNG1
CASP1
CASP6
CCDC120
CCNG1
CD52
CD72
CD81
CDK1
CDS2
CENPP
CETN3
CFHR5
CHST1
CLCA4
CLCN7
CLDN10
CLDND2
CLEC1A
CLEC4A
CLK1
CLN6
CMTM3
CMTM5
CMTM7
CNIH3
COL8A2
COX14
CREB3
CRY2
CSGALNACT2
CTSA
CWF19L2
CXCL14
CXCL16
CYB561
CYB561D2
CYB5B
CYBC1
CYBRD1
DBNDD2
DDX24
DDX43
DEFB127
DERL1
DERL2
DNAJC30
DUS3L
DUSP13
EDDM3B
EGF
EIF3G
ELOA
EMD
ENTPD3
ERG28
F2RL1
FA2H
FAIM
FAM161A
FAM3C
FAM9B
FATE1
FAXDC2
FBXO7
FCER1A
FCER1G
FDFT1
FETUB
FLNA
FOS
FXYD3
FXYD6
GALNT2
GIN1
GJB2
GJB5
GOLGA2P10
GOLT1B
GOSR2
GPR108
GPR25
GRM2
GZMA
GZMB
HACD1
HCK
HMOX1
HMOX2
IFFO1
IFIT2
IGFBP5
INSIG2
ITGAM
ITM2B
IZUMO2
JAGN1
KASH5
KAT5
KCNK1
KCNK13
KIF12
KPNA6
KRT6A
KRTAP10-3
KRTAP10-7
LAMB1
LAT
LCP2
LEPROTL1
LHFPL5
LIMS2
LINC01587
LMBR1
LMNB1
LMNB2
LPAR3
LRP10
LVRN
MAL
MALL
MAPRE2
MARVELD1
MATR3
MCM5
MEOX1
MFAP1
MFSD5
MGLL
MGST3
MIP
MLIP
MMD2
MORF4L1
MRPS26
MS4A1
MTHFD2
MUTYH
MYADM
NAB2
NALCN
NARF
NAT8
NEU1
NINJ2
NIPAL3
NKG7
NOD2
NTAQ1
ORMDL1
ORMDL3
OSBPL8
OSTCP1
OSTF1
PAQR5
PARPBP
PCBP1
PCGF2
PCNA
PELI1
PERM1
PIAS2
PIK3R2
PKD2
PLLP
PLP1
PLP2
PLPP4
PMP22
PNKP
PNLIPRP1
PRELID3A
PRKCA
PRNP
PTPN9
PYGM
RABAC1
RANBP9
RB1
RBBP4
REEP6
RGS18
RHAG
RMDN2
RNF123
RPRM
RTN1
RTN3
RTN4
RUSF1
SACM1L
SBDS
SCARA3
SCARB2
SEC22A
SEC22B
SELENOK
SENP2
SERP1
SERP2
SERPINE1
SFT2D2
SFTPC
SGMS2
SH3RF2
SIAH1
SLC13A3
SLC1A1
SLC2A5
SLC30A2
SLC30A3
SLC30A8
SLC35A1
SLC35A4
SLC35B2
SLC35B4
SLC38A7
SLC41A2
SLC7A1
SLN
SLU7
SMAD1
SMAD3
SMCO4
SMIM11A
SMURF1
SMURF2
SNORC
SPANXC
SPANXD
SPG21
SPN
SREBF1
SRPK2
STAC
STAC2
STARD3
STX12
STX3
STX4
STX5
STX6
STX7
STX8
SUMO2
SUMO4
SVIL
SYCE1
SYNE1
SYNGR1
SYPL1
SYT6
TAP1
TCEA2
TCEANC
TDO2
TFRC
THBD
TM4SF20
TMEM107
TMEM109
TMEM11
TMEM120B
TMEM128
TMEM140
TMEM14A
TMEM14B
TMEM14C
TMEM199
TMEM201
TMEM203
TMEM208
TMEM218
TMEM222
TMEM230
TMEM234
TMEM243
TMEM267
TMEM41A
TMEM42
TMEM43
TMEM51
TMEM54
TMEM60
TMEM65
TMEM74
TMEM86A
TMPO
TMPRSS4
TNF
TNFRSF10C
TNFSF12
TNMD
TOR1A
TOR1AIP1
TRAM1L1
TRIM26
TRIM39
TSGA10
TSNARE1
TSPAN2
TSPAN33
TSPAN7
UBE2I
UBE2Q1
UBQLNL
UCHL5
UNC13D
UNC45A
UNC50
UPK1B
URB2
USE1
USP2
USP20
VAMP1
VAMP2
VAMP3
VAMP5
VKORC1
VMP1
VSTM1
VTI1B
WFDC2
YIPF1
YIPF6
YWHAQ
ZC2HC1C
ZDHHC15
ZDHHC24
ZMYM6
ZNF138
ZNF239
ZNF25
ZNF3
ZNF439
ZNF440
ZNF490
ZNF564
ZNF569
ZNF69
ZSCAN12
139 interacting genes:
AIMP2
AMOTL2
APP
ATP5F1B
AXIN2
BEND7
BFSP1
BHLHE40
C1orf94
CAVIN4
CCDC102B
CCDC136
CCDC33
CDC23
CDCA7L
CEP44
CEP57L1
CEP70
COIL
DDX17
DOCK8
DVL2
EAPP
EMD
EPS8
FAM228A
FAM9B
FCHO1
FXR1
FXR2
GAS8
GMCL1
GOLGA2
GOLGA6L9
GRIPAP1
HMBOX1
HOMEZ
HOOK2
HSF2BP
IKZF1
IKZF3
JRK
KATNAL1
KIFC3
KLHL2
KLHL6
KRT31
KRT40
KRT8
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP4-2
L3MBTL3
LDOC1
LHX3
LMNA
LMO1
LMO2
LONRF1
LTV1
LZTS1
LZTS2
MB21D2
MCIDAS
MEOX1
MEOX2
MID1
MID2
MIPOL1
MKRN1
MRFAP1L1
MTUS2
NECAB2
NF2
OLIG3
OSBPL3
PDE4DIP
PHC2
PICK1
PIH1D1
PNMA1
PNMA2
PRICKLE1
PSMC6
RACGAP1
RACK1
RALY
RALYL
RBAK
RP9
RUBCN
SMN1
SMN2
SNW1
SSX2IP
STX11
TBC1D26
TEKT1
TFIP11
THAP1
TLE5
TNIP1
TRAF2
TRAF4
TRAK1
TRIM14
TRIM27
TRIM37
TRIM38
TRIM41
TRIM54
TRIM55
TRIP6
TRO
TROAP
UBE2H
USH1G
VIM
VPS37B
VPS52
WASF3
WTAP
ZBTB14
ZBTB8A
ZC2HC1C
ZFP64
ZMAT5
ZNF212
ZNF286A
ZNF426
ZNF438
ZNF48
ZNF655
ZNF668
ZNF71
ZNF835
ZRANB1
ZSCAN22
Entrez ID
4000
705
HPRD ID
01035
04848
Ensembl ID
ENSG00000160789
ENSG00000112578
Uniprot IDs
A0A384MQX1
P02545
Q5TCI8
Q13895
PDB IDs
1IFR
1IVT
1X8Y
2XV5
2YPT
3GEF
3V4Q
3V4W
3V5B
6GHD
6JLB
6RPR
6SNZ
6YF5
6G18
6G4S
6G4W
Enriched GO Terms of Interacting Partners
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