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DERL1 and SELENOS
Data Source:
HPRD
(in vitro, in vivo)
DERL1
SELENOS
Description
derlin 1
selenoprotein S
Image
GO Annotations
Cellular Component
Hrd1p Ubiquitin Ligase ERAD-L Complex
Early Endosome
Late Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Derlin-1-VIMP Complex
Derlin-1 Retrotranslocation Complex
Endoplasmic Reticulum Quality Control Compartment
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytoplasmic Microtubule
Plasma Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Very-low-density Lipoprotein Particle
Low-density Lipoprotein Particle
Derlin-1-VIMP Complex
Derlin-1 Retrotranslocation Complex
Molecular Function
Protease Binding
Signal Recognition Particle Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
MHC Class I Protein Binding
Identical Protein Binding
Protein-containing Complex Binding
ATPase Binding
Misfolded Protein Binding
Ubiquitin-specific Protease Binding
Protein Binding
Antioxidant Activity
Enzyme Binding
Signaling Receptor Activity
ATPase Binding
Ubiquitin-specific Protease Binding
Biological Process
Protein Folding
Response To Unfolded Protein
Viral Process
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Positive Regulation Of Protein Binding
ERAD Pathway
Establishment Of Protein Localization
Transmembrane Transport
ER-associated Misfolded Protein Catabolic Process
Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus
Regulation Of Gluconeogenesis
ER Overload Response
Response To Glucose
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Cellular Response To Insulin Stimulus
Cellular Response To Oxidative Stress
Establishment Of Protein Localization
Cell Redox Homeostasis
Negative Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of Glucose Import
Negative Regulation Of Inflammatory Response
Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process
Response To Redox State
Cellular Response To Lipopolysaccharide
Regulation Of Nitric Oxide Metabolic Process
Cellular Oxidant Detoxification
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Macrophage Apoptotic Process
Pathways
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Defective CFTR causes cystic fibrosis
E3 ubiquitin ligases ubiquitinate target proteins
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS
Mean reticulocyte volume (
32888494
)
Metabolite levels (
23823483
)
Interacting Genes
33 interacting genes:
ABHD4
AMFR
APP
AQP6
CFTR
CIAO2A
FCRL4
FFAR2
GAD2
HLA-A
KASH5
LMNA
LNX1
MELTF
REEP4
RETREG3
RHO
SCN3B
SELENOS
SLC10A1
SLC10A6
SLC30A8
SLC7A14
SLC7A8
TCF25
TEX44
TMED8
TMEM31
TMX2
TRIM32
UBE2J1
UBXN6
VCP
9 interacting genes:
APOA5
DERL1
GTF2IRD1
KLHDC2
KPNB1
MFHAS1
SAA1
SRPK2
VCP
Entrez ID
79139
55829
HPRD ID
12302
12133
Ensembl ID
ENSG00000136986
ENSG00000131871
Uniprot IDs
A0A024R9G3
E5RGY0
Q9BUN8
Q6GYA4
Q9BQE4
PDB IDs
5GLF
2Q2F
5KIU
5KIY
6DO4
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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