LMNA and FBXO7

Data Source:
BioGRID (enzymatic study)

		LMNA	FBXO7
Description		lamin A/C	F-box protein 7
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Lamina Nucleoplasm Cytosol Intermediate Filament Nuclear Matrix Nuclear Body Nuclear Speck Nuclear Membrane Site Of Double-strand Break	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol SCF Ubiquitin Ligase Complex Protein-containing Complex Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Neurite Lewy Body Core Lewy Body Corona
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Protein Heterodimerization Activity Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Mitotic Nuclear Envelope Reassembly Negative Regulation Of Cell Population Proliferation Regulation Of Cell Migration Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Protein Localization To Nucleus IRE1-mediated Unfolded Protein Response Cellular Response To Hypoxia Positive Regulation Of Cell Aging Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress DNA Double-strand Break Attachment To Nuclear Envelope	Protein Polyubiquitination Autophagy Of Mitochondrion Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Mitochondrion Regulation Of Neuron Projection Development Protein Ubiquitination Regulation Of Protein Stability Regulation Of Locomotion Post-translational Protein Modification Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		XBP1(S) activates chaperone genes Signaling by BRAF and RAF fusions	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Restrictive dermopathy Emery-Dreifuss muscular dystrophy Dilated cardiomyopathy (DCM) Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Mandibuloacral dysplasia Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Limb-girdle muscular dystrophy (LGMD) Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy Hutchinson-Gilford progeria syndrome	Parkinson's disease (PD)
GWAS		Birth weight ( 31043758) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Ischemic heart disease in rheumatoid arthritis ( 30251476) Lung cancer in ever smokers ( 28604730) Neutrophil count ( 32888494) Ovarian cancer ( 30557369) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) White blood cell count ( 32888494)	Blood protein levels ( 29875488) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278)
Interacting Genes		381 interacting genes: ABCA9 ACOT7 ACTB ADAM33 ADGRE2 ADGRG7 AGTRAP AIG1 AKTIP ALG3 ALG8 ALOX12 ALOX12B ANKRD20A5P ANXA6 AOC3 APOA2 APOD APOL2 AQP1 AQP10 AQP3 ARHGEF16 ARL6IP1 ASGR1 ATP6V0C BCL2L2 BNIP2 BNIP3 BNIP3L BRICD5 BTN2A2 BYSL C11orf24 C1QTNF1 C20orf141 C3orf52 C4orf3 C5 CACNG1 CASP1 CASP6 CCDC120 CCNG1 CD52 CD72 CD81 CDK1 CDS2 CENPP CETN3 CFHR5 CHST1 CLCA4 CLCN7 CLDN10 CLDND2 CLEC1A CLEC4A CLK1 CLN6 CMTM3 CMTM5 CMTM7 CNIH3 COL8A2 COX14 CREB3 CRY2 CSGALNACT2 CTSA CWF19L2 CXCL14 CXCL16 CYB561 CYB561D2 CYB5B CYBC1 CYBRD1 DBNDD2 DDX24 DDX43 DEFB127 DERL1 DERL2 DNAJC30 DUS3L DUSP13 EDDM3B EGF EIF3G ELOA EMD ENTPD3 ERG28 F2RL1 FA2H FAIM FAM161A FAM3C FAM9B FATE1 FAXDC2 FBXO7 FCER1A FCER1G FDFT1 FETUB FLNA FOS FXYD3 FXYD6 GALNT2 GIN1 GJB2 GJB5 GOLGA2P10 GOLT1B GOSR2 GPR108 GPR25 GRM2 GZMA GZMB HACD1 HCK HMOX1 HMOX2 IFFO1 IFIT2 IGFBP5 INSIG2 ITGAM ITM2B IZUMO2 JAGN1 KASH5 KAT5 KCNK1 KCNK13 KIF12 KPNA6 KRT6A KRTAP10-3 KRTAP10-7 LAMB1 LAT LCP2 LEPROTL1 LHFPL5 LIMS2 LINC01587 LMBR1 LMNB1 LMNB2 LPAR3 LRP10 LVRN MAL MALL MAPRE2 MARVELD1 MATR3 MCM5 MEOX1 MFAP1 MFSD5 MGLL MGST3 MIP MLIP MMD2 MORF4L1 MRPS26 MS4A1 MTHFD2 MUTYH MYADM NAB2 NALCN NARF NAT8 NEU1 NINJ2 NIPAL3 NKG7 NOD2 NTAQ1 ORMDL1 ORMDL3 OSBPL8 OSTCP1 OSTF1 PAQR5 PARPBP PCBP1 PCGF2 PCNA PELI1 PERM1 PIAS2 PIK3R2 PKD2 PLLP PLP1 PLP2 PLPP4 PMP22 PNKP PNLIPRP1 PRELID3A PRKCA PRNP PTPN9 PYGM RABAC1 RANBP9 RB1 RBBP4 REEP6 RGS18 RHAG RMDN2 RNF123 RPRM RTN1 RTN3 RTN4 RUSF1 SACM1L SBDS SCARA3 SCARB2 SEC22A SEC22B SELENOK SENP2 SERP1 SERP2 SERPINE1 SFT2D2 SFTPC SGMS2 SH3RF2 SIAH1 SLC13A3 SLC1A1 SLC2A5 SLC30A2 SLC30A3 SLC30A8 SLC35A1 SLC35A4 SLC35B2 SLC35B4 SLC38A7 SLC41A2 SLC7A1 SLN SLU7 SMAD1 SMAD3 SMCO4 SMIM11A SMURF1 SMURF2 SNORC SPANXC SPANXD SPG21 SPN SREBF1 SRPK2 STAC STAC2 STARD3 STX12 STX3 STX4 STX5 STX6 STX7 STX8 SUMO2 SUMO4 SVIL SYCE1 SYNE1 SYNGR1 SYPL1 SYT6 TAP1 TCEA2 TCEANC TDO2 TFRC THBD TM4SF20 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM14C TMEM199 TMEM201 TMEM203 TMEM208 TMEM218 TMEM222 TMEM230 TMEM234 TMEM243 TMEM267 TMEM41A TMEM42 TMEM43 TMEM51 TMEM54 TMEM60 TMEM65 TMEM74 TMEM86A TMPO TMPRSS4 TNF TNFRSF10C TNFSF12 TNMD TOR1A TOR1AIP1 TRAM1L1 TRIM26 TRIM39 TSGA10 TSNARE1 TSPAN2 TSPAN33 TSPAN7 UBE2I UBE2Q1 UBQLNL UCHL5 UNC13D UNC45A UNC50 UPK1B URB2 USE1 USP2 USP20 VAMP1 VAMP2 VAMP3 VAMP5 VKORC1 VMP1 VSTM1 VTI1B WFDC2 YIPF1 YIPF6 YWHAQ ZC2HC1C ZDHHC15 ZDHHC24 ZMYM6 ZNF138 ZNF239 ZNF25 ZNF3 ZNF439 ZNF440 ZNF490 ZNF564 ZNF569 ZNF69 ZSCAN12	345 interacting genes: AATF ABCF3 ABL1 ACOT8 ACSL5 ACSM3 ACTC1 ACVR1 ACVR2B AK8 AKAP14 AKIRIN2 AKT3 ALKBH3 AMOTL2 ANGPTL7 ANKRD36BP1 ANP32E APEX1 APOBEC3C APOBEC4 ASPH ASPHD1 ATAT1 ATF5 ATP5F1C BAG3 BCKDK BIRC2 BLK BUB1 BUB1B C11orf16 C15orf48 C1orf105 C1orf115 C22orf31 C2orf88 CACYBP CAMK1 CAPN5 CASQ2 CCBE1 CCDC186 CCDC60 CCDC88C CCNE2 CDC34 CDK10 CDK14 CENPJ CEP112 CFAP300 CHCHD2 CHCHD6 CHMP2B CHMP3 CILK1 CIRBP CKAP2 CLHC1 CLIP3 CMTR2 CNOT7 COLEC12 CPEB4 CSNK1E CXCL12 CXCL9 DDRGK1 DDX10 DHRS2 DHX40 DNAH14 DNAJA3 DNAJB12 DNAJC30 DPY19L2P1 DRAP1 ELF4 EP400P1 EPHA3 EPHB2 EPHB3 EPHB4 ERBB2 ERICH2 FGF10 FGF13 FGFR1 FGFR2 FMOD FUT8 FYTTD1 GADD45GIP1 GAPDH GBP2 GEMIN2 GGA2 GLCE GLIPR2 GLRX2 GMCL2 GNLY GORAB GPAM GPKOW GRK6 GSK3B H1-0 H2AZ2 H3-3B HADH HMG20A HMG20B HMGB2 HMGCS2 HNRNPK HPF1 IDH2 IFT88 IGKV1-5 IL4 IL7 ILKAP INKA2 INPP5K INTS7 IPO9 IRF3 JADE2 KCNAB1 KCTD14 KHDRBS3 KIAA1586 KIF12 KIFC3 KIRREL3-AS3 KLF4 KMO KPNA5 LETMD1 LGALS3BP LIMK1 LIMK2 LINC01483 LMNA LRRC20 LRRC8E LRRFIP1 MAK MAP2K6 MAPK10 MAPK9 MAPRE2 MARK2 MARK3 MBD5 MBNL1 MCM2 MCM5 MDK MED22 MED27 MEF2D MEST MIR1-1HG-AS1 MIS18BP1 MITF MMP13 MMP8 MNDA MOB3A MOB3C MPG MPP3 MPZL1 MRM3 MRPL27 MRPS14 MTIF3 MTUS1 MYOG NANS NDE1 NFIA NFIC NKD2 NPHP1 NUDT16L1 NUMB NVL ODF2L OLFML2A OR14K1 ORC3 OSTF1 PABPC3 PACRG PAFAH1B1 PAK6 PCBD2 PDCD7 PDE12 PDE4D PDGFB PGAP4 PHLDA1 PIEZO1 PIGY PIM1 PIM2 PINK1 PLEKHA1 PNOC PNRC2 POLDIP2 POLR2K PPHLN1 PPP1CB PPP1R17 PPP1R21 PRAME PRICKLE2 PRKACB PRKCA PRKCB PRKCG PRKN PRMT1 PRRC2B PUF60 PUSL1 QKI RBBP6 RBM23 RBM33 RCC1 REEP3 REEP4 RET RGS1 RGS22 RNF121 RNF20 RORB RPL14 RPL26 RPL36A RPL37A RPL3L RPL6 RPS15A RPS18 RPS19BP1 RPS2 RPS6KA3 RPS6KB1 RSL24D1 RWDD4 S100A13 S100A16 S100B SAMHD1 SCARA5 SDCCAG8 SEC16B SEC24C SET SFR1 SHMT1 SHMT2 SKP1 SLAIN1 SLC25A26 SLC35B3 SLC7A6OS SMARCD1 SMOC2 SNAP25 SNRPA SNX33 SPATA4 SPDYA SPRY2 SRCIN1 SRPK3 SRSF10 SRSF7 SS18L2 STAT6 STYX TAF9B TARDBP TBC1D3P2 TBPL1 TC2N TCP10L3 TEAD4 TEC TECR TECRL TENT5D TEX29 TGIF2 THAP7 TLE3 TMED10 TMEM120A TMEM237 TMOD2 TMPRSS5 TOMM20 TRAPPC12 TRIB3 TRIM44 TSBP1 TSLP UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2J2 UBE2M UROD USF1 USH1C UXS1 UXT VPS16 VRK3 WDR18 WDR24 XPO1 XRN1 YPEL5 ZBTB44 ZC2HC1C ZFYVE21 ZKSCAN8 ZMYM5 ZNF462 ZNF574 ZNF684 ZNF688
Entrez ID		4000	25793
HPRD ID		01035	07292
Ensembl ID		ENSG00000160789	ENSG00000100225
Uniprot IDs		A0A384MQX1 P02545 Q5TCI8	Q9Y3I1
PDB IDs		1IFR 1IVT 1X8Y 2XV5 2YPT 3GEF 3V4Q 3V4W 3V5B 6GHD 6JLB 6RPR 6SNZ 6YF5	4L9C 4L9H
Enriched GO Terms of Interacting Partners?
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