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LMNA and TMEM14B
Data Source:
BioGRID
(two hybrid)
LMNA
TMEM14B
Description
lamin A/C
transmembrane protein 14B
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nuclear Lamina
Nucleoplasm
Cytosol
Intermediate Filament
Nuclear Matrix
Nuclear Body
Nuclear Speck
Nuclear Membrane
Site Of Double-strand Break
Mitochondrial Inner Membrane
Integral Component Of Membrane
Mitochondrial Membrane
Molecular Function
Protein Binding
Protein Binding
Identical Protein Binding
Biological Process
Mitotic Nuclear Envelope Reassembly
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Migration
Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity
Protein Localization To Nucleus
IRE1-mediated Unfolded Protein Response
Cellular Response To Hypoxia
Positive Regulation Of Cell Aging
Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
DNA Double-strand Break Attachment To Nuclear Envelope
Mitochondrial Transport
Cerebral Cortex Development
Neural Precursor Cell Proliferation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
XBP1(S) activates chaperone genes
Signaling by BRAF and RAF fusions
Drugs
Diseases
Restrictive dermopathy
Emery-Dreifuss muscular dystrophy
Dilated cardiomyopathy (DCM)
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
Mandibuloacral dysplasia
Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
Limb-girdle muscular dystrophy (LGMD)
Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
Hutchinson-Gilford progeria syndrome
GWAS
Birth weight (
31043758
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Ischemic heart disease in rheumatoid arthritis (
30251476
)
Lung cancer in ever smokers (
28604730
)
Neutrophil count (
32888494
)
Ovarian cancer (
30557369
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Urate levels (
31578528
)
White blood cell count (
32888494
)
Response to (pegylated) interferon in HBeAg-negative hepatitis B (
30715261
)
Interacting Genes
381 interacting genes:
ABCA9
ACOT7
ACTB
ADAM33
ADGRE2
ADGRG7
AGTRAP
AIG1
AKTIP
ALG3
ALG8
ALOX12
ALOX12B
ANKRD20A5P
ANXA6
AOC3
APOA2
APOD
APOL2
AQP1
AQP10
AQP3
ARHGEF16
ARL6IP1
ASGR1
ATP6V0C
BCL2L2
BNIP2
BNIP3
BNIP3L
BRICD5
BTN2A2
BYSL
C11orf24
C1QTNF1
C20orf141
C3orf52
C4orf3
C5
CACNG1
CASP1
CASP6
CCDC120
CCNG1
CD52
CD72
CD81
CDK1
CDS2
CENPP
CETN3
CFHR5
CHST1
CLCA4
CLCN7
CLDN10
CLDND2
CLEC1A
CLEC4A
CLK1
CLN6
CMTM3
CMTM5
CMTM7
CNIH3
COL8A2
COX14
CREB3
CRY2
CSGALNACT2
CTSA
CWF19L2
CXCL14
CXCL16
CYB561
CYB561D2
CYB5B
CYBC1
CYBRD1
DBNDD2
DDX24
DDX43
DEFB127
DERL1
DERL2
DNAJC30
DUS3L
DUSP13
EDDM3B
EGF
EIF3G
ELOA
EMD
ENTPD3
ERG28
F2RL1
FA2H
FAIM
FAM161A
FAM3C
FAM9B
FATE1
FAXDC2
FBXO7
FCER1A
FCER1G
FDFT1
FETUB
FLNA
FOS
FXYD3
FXYD6
GALNT2
GIN1
GJB2
GJB5
GOLGA2P10
GOLT1B
GOSR2
GPR108
GPR25
GRM2
GZMA
GZMB
HACD1
HCK
HMOX1
HMOX2
IFFO1
IFIT2
IGFBP5
INSIG2
ITGAM
ITM2B
IZUMO2
JAGN1
KASH5
KAT5
KCNK1
KCNK13
KIF12
KPNA6
KRT6A
KRTAP10-3
KRTAP10-7
LAMB1
LAT
LCP2
LEPROTL1
LHFPL5
LIMS2
LINC01587
LMBR1
LMNB1
LMNB2
LPAR3
LRP10
LVRN
MAL
MALL
MAPRE2
MARVELD1
MATR3
MCM5
MEOX1
MFAP1
MFSD5
MGLL
MGST3
MIP
MLIP
MMD2
MORF4L1
MRPS26
MS4A1
MTHFD2
MUTYH
MYADM
NAB2
NALCN
NARF
NAT8
NEU1
NINJ2
NIPAL3
NKG7
NOD2
NTAQ1
ORMDL1
ORMDL3
OSBPL8
OSTCP1
OSTF1
PAQR5
PARPBP
PCBP1
PCGF2
PCNA
PELI1
PERM1
PIAS2
PIK3R2
PKD2
PLLP
PLP1
PLP2
PLPP4
PMP22
PNKP
PNLIPRP1
PRELID3A
PRKCA
PRNP
PTPN9
PYGM
RABAC1
RANBP9
RB1
RBBP4
REEP6
RGS18
RHAG
RMDN2
RNF123
RPRM
RTN1
RTN3
RTN4
RUSF1
SACM1L
SBDS
SCARA3
SCARB2
SEC22A
SEC22B
SELENOK
SENP2
SERP1
SERP2
SERPINE1
SFT2D2
SFTPC
SGMS2
SH3RF2
SIAH1
SLC13A3
SLC1A1
SLC2A5
SLC30A2
SLC30A3
SLC30A8
SLC35A1
SLC35A4
SLC35B2
SLC35B4
SLC38A7
SLC41A2
SLC7A1
SLN
SLU7
SMAD1
SMAD3
SMCO4
SMIM11A
SMURF1
SMURF2
SNORC
SPANXC
SPANXD
SPG21
SPN
SREBF1
SRPK2
STAC
STAC2
STARD3
STX12
STX3
STX4
STX5
STX6
STX7
STX8
SUMO2
SUMO4
SVIL
SYCE1
SYNE1
SYNGR1
SYPL1
SYT6
TAP1
TCEA2
TCEANC
TDO2
TFRC
THBD
TM4SF20
TMEM107
TMEM109
TMEM11
TMEM120B
TMEM128
TMEM140
TMEM14A
TMEM14B
TMEM14C
TMEM199
TMEM201
TMEM203
TMEM208
TMEM218
TMEM222
TMEM230
TMEM234
TMEM243
TMEM267
TMEM41A
TMEM42
TMEM43
TMEM51
TMEM54
TMEM60
TMEM65
TMEM74
TMEM86A
TMPO
TMPRSS4
TNF
TNFRSF10C
TNFSF12
TNMD
TOR1A
TOR1AIP1
TRAM1L1
TRIM26
TRIM39
TSGA10
TSNARE1
TSPAN2
TSPAN33
TSPAN7
UBE2I
UBE2Q1
UBQLNL
UCHL5
UNC13D
UNC45A
UNC50
UPK1B
URB2
USE1
USP2
USP20
VAMP1
VAMP2
VAMP3
VAMP5
VKORC1
VMP1
VSTM1
VTI1B
WFDC2
YIPF1
YIPF6
YWHAQ
ZC2HC1C
ZDHHC15
ZDHHC24
ZMYM6
ZNF138
ZNF239
ZNF25
ZNF3
ZNF439
ZNF440
ZNF490
ZNF564
ZNF569
ZNF69
ZSCAN12
229 interacting genes:
ABHD16A
ABHD5
ACSL5
ADAM33
AGPAT3
AGPAT4
AGR3
AGTRAP
APOC2
APOC4
ARL6IP1
ARL8B
ARV1
ATP13A1
B4GALT7
BIK
BLCAP
BMP10
BTN2A2
C10orf67
C14orf180
C1GALT1
C2CD2L
CCL4
CD79A
CEPT1
CFHR5
CIDEB
CLDN10
CLDND2
CMTM5
CMTM8
CNIH2
CNIH3
CNIH4
COMT
CPLX4
CREB3
CREB3L1
CXCL16
CYB561
CYB5R3
DEFB103A
DEFB103B
DGAT2L6
DHRSX
EBP
EI24
EMC6
EPHX4
ERGIC3
EXTL1
FA2H
FADS6
FAM209A
FCER1G
FHL3
FIS1
FKBP8
FXYD6-FXYD2
GDAP1
GIMAP1
GPR152
GPX8
GYPA
GYPC
HEXB
HIBADH
HIGD1C
HMOX1
HMOX2
HSD17B11
HSD3B1
IER3IP1
IFITM3
INSIG2
ITGAM
JAGN1
KCNA1
KCNK1
KHDRBS2
LEPROTL1
LMNA
LPAR3
LRCH1
MAL2
MARCHF5
MEOX2
MFSD12
MFSD5
MGAM
MID2
MMD2
MS4A13
MS4A4A
NAT8
NCALD
NDUFA3
NEU1
NINJ1
NINJ2
NIPAL3
ORMDL1
OTULINL
PAGE1
PDPN
PDZK1IP1
PEX11G
PIGF
PLLP
PLP1
PLP2
PMP22
PNLIPRP1
PPP2R3B
PRAF2
PRH1
PRTFDC1
PSMD3
PTPMT1
RABAC1
RHD
RHOT2
SAR1B
SCAMP5
SCN3B
SCRG1
SERF1A
SERF1B
SERP1
SERP2
SFT2D1
SFT2D2
SFXN1
SFXN2
SFXN3
SLC16A10
SLC16A13
SLC18A1
SLC19A3
SLC2A6
SLC30A3
SLC30A8
SLC35A4
SLC35C2
SLC35E3
SLC35E4
SLC35F1
SLC35F6
SLC35G1
SLC39A2
SLC39A7
SLC48A1
SLC7A8
SMAGP
SMPD2
SPRY2
SQLE
ST6GAL2
STOM
STX12
STX3
STX6
STX8
SUCNR1
SYNGR1
SYNJ2BP
TAP1
TAS2R19
TBC1D20
TEX44
THBD
TIMM22
TIMM23
TIMMDC1
TLCD1
TM4SF4
TMEM11
TMEM120A
TMEM120B
TMEM121
TMEM147
TMEM14A
TMEM14C
TMEM187
TMEM19
TMEM199
TMEM203
TMEM220
TMEM222
TMEM229B
TMEM243
TMEM254
TMEM255B
TMEM267
TMEM42
TMEM50A
TMEM50B
TMEM51
TMEM60
TMEM69
TMEM97
TMIE
TMUB1
TMX2
TOMM6
TSPAN2
TSPO
TVP23B
UBE2J1
UBE2J2
UBE3A
UBIAD1
UBXN8
UNC50
UNC93A
VAMP1
VAMP5
VRK2
VTI1B
YIF1A
YIPF1
YIPF2
YIPF4
YIPF6
ZDHHC11
ZDHHC22
ZDHHC24
ZFPL1
Entrez ID
4000
81853
HPRD ID
01035
15523
Ensembl ID
ENSG00000160789
ENSG00000137210
Uniprot IDs
A0A384MQX1
P02545
Q5TCI8
A0A024QZV7
A0A087WU83
C9JCY4
C9JQS0
Q9NUH8
PDB IDs
1IFR
1IVT
1X8Y
2XV5
2YPT
3GEF
3V4Q
3V4W
3V5B
6GHD
6JLB
6RPR
6SNZ
6YF5
Enriched GO Terms of Interacting Partners
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