Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
USP15 and BMPR1A
Data Source:
BioGRID
(enzymatic study)
USP15
BMPR1A
Description
ubiquitin specific peptidase 15
bone morphogenetic protein receptor type 1A
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Integral Component Of Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
HFE-transferrin Receptor Complex
Molecular Function
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Identical Protein Binding
SMAD Binding
Ubiquitin Modification-dependent Histone Binding
Lys48-specific Deubiquitinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Protein Homodimerization Activity
SMAD Binding
Metal Ion Binding
BMP Receptor Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Viral Process
Protein Deubiquitination
Protein Phosphopantetheinylation
BMP Signaling Pathway
Monoubiquitinated Protein Deubiquitination
Histone H2B Conserved C-terminal Lysine Deubiquitination
Pathway-restricted SMAD Protein Phosphorylation
Protein K48-linked Deubiquitination
Positive Regulation Of RIG-I Signaling Pathway
In Utero Embryonic Development
Mesoderm Formation
Somitogenesis
Mullerian Duct Regression
Positive Regulation Of Mesenchymal Cell Proliferation
Chondrocyte Differentiation
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Cardiac Conduction System Development
Mitral Valve Morphogenesis
Tricuspid Valve Morphogenesis
Endocardial Cushion Morphogenesis
Cardiac Right Ventricle Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Endocardial Cushion Formation
Protein Phosphorylation
Immune Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Ectoderm Development
Dorsal/ventral Axis Specification
Dorsal/ventral Pattern Formation
Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Neural Crest Cell Development
Negative Regulation Of Smooth Muscle Cell Migration
Stem Cell Population Maintenance
Pituitary Gland Development
Neural Plate Mediolateral Regionalization
Lung Development
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Hindlimb Morphogenesis
Dorsal Aorta Morphogenesis
Odontogenesis Of Dentin-containing Tooth
Embryonic Digit Morphogenesis
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Structural Organization
Lateral Mesoderm Development
Regulation Of Lateral Mesodermal Cell Fate Specification
Mesendoderm Development
Embryonic Organ Development
Developmental Growth
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Neurogenesis
Roof Of Mouth Development
Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of SMAD Protein Signal Transduction
Heart Formation
BMP Signaling Pathway Involved In Heart Development
Pharyngeal Arch Artery Morphogenesis
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Cardiac Ventricle Development
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Fibrous Ring Of Heart Morphogenesis
Regulation Of Neural Crest Cell Differentiation
Regulation Of Cellular Senescence
Pathways
Downregulation of TGF-beta receptor signaling
UCH proteinases
Ub-specific processing proteases
Signaling by BMP
Drugs
Dibotermin alfa
Diseases
Hereditary mixed polyposis syndrome
Juvenile polyposis syndrome
GWAS
Alopecia areata (
25608926
)
Metabolite levels (
23823483
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Pulmonary function decline (
22424883
)
Pyoderma gangrenosum in inflammatory bowel disease (
24487271
)
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
White blood cell count (
32888494
)
Interacting Genes
55 interacting genes:
BAP1
BMI1
BMPR1A
BRAP
CARD9
CCDC57
DDX58
FHL1
GEMIN4
GOLGA2
GOLGA6A
H2BC21
IL1R2
JOSD1
KEAP1
MAD1L1
MDC1
MDM2
OTUB1
PHF7
PIBF1
PLA2G2A
PRPF31
RBCK1
RNF126
RNF144B
SENP3
SENP8
SMURF2
SPDL1
STAM
STK33
SYVN1
TEX11
TRAF6
TRIM17
TRIM21
TRIM25
TRIM46
TRIM5
TRIM54
TRIM63
TRIM74
UBE2S
UCHL1
UCHL3
USP14
USP2
USP20
USP21
USP28
USP33
USP51
USP8
YOD1
45 interacting genes:
ACVR1
ALDOB
AOPEP
BAMBI
BMP2
BMP4
BMP5
BMP6
BMP7
BMPR1B
BMPR2
CDK8
CTSV
FANCC
FBP1
FBP2
FKBP1A
FKBP1B
GALNT12
GDF5
GDF6
GDF9
HOXC8
HRAS
IGFBP3
MAP2K1
MSANTD3
NEDD4
NEDD4L
OTUB1
RASA1
SEC61B
SF3B4
SFRP2
SFRP4
SMAD1
TAB1
TDGF1
TGFB1
TGFBRAP1
TRMO
USP15
XPA
ZMYND11
ZNF189
Entrez ID
9958
657
HPRD ID
05293
03192
Ensembl ID
ENSG00000135655
ENSG00000107779
Uniprot IDs
Q9Y4E8
P36894
PDB IDs
1W6V
3LMN
3PPA
3PV1
3T9L
4A3O
4A3P
5JJW
6CPM
6CRN
6DJ9
6GH9
6GHA
6ML1
1ES7
1REW
2GOO
2H62
2H64
2K3G
2QJ9
2QJA
2QJB
3NH7
3QB4
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?