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USP15 and TRIM74
Data Source:
BioGRID
(two hybrid)
USP15
TRIM74
Description
ubiquitin specific peptidase 15
tripartite motif containing 74
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Cytoplasm
Cytosol
Molecular Function
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Identical Protein Binding
SMAD Binding
Ubiquitin Modification-dependent Histone Binding
Lys48-specific Deubiquitinase Activity
Zinc Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Viral Process
Protein Deubiquitination
Protein Phosphopantetheinylation
BMP Signaling Pathway
Monoubiquitinated Protein Deubiquitination
Histone H2B Conserved C-terminal Lysine Deubiquitination
Pathway-restricted SMAD Protein Phosphorylation
Protein K48-linked Deubiquitination
Positive Regulation Of RIG-I Signaling Pathway
Protein Ubiquitination
Pathways
Downregulation of TGF-beta receptor signaling
UCH proteinases
Ub-specific processing proteases
Drugs
Diseases
GWAS
Alopecia areata (
25608926
)
Metabolite levels (
23823483
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Pulmonary function decline (
22424883
)
Pyoderma gangrenosum in inflammatory bowel disease (
24487271
)
Interacting Genes
55 interacting genes:
BAP1
BMI1
BMPR1A
BRAP
CARD9
CCDC57
DDX58
FHL1
GEMIN4
GOLGA2
GOLGA6A
H2BC21
IL1R2
JOSD1
KEAP1
MAD1L1
MDC1
MDM2
OTUB1
PHF7
PIBF1
PLA2G2A
PRPF31
RBCK1
RNF126
RNF144B
SENP3
SENP8
SMURF2
SPDL1
STAM
STK33
SYVN1
TEX11
TRAF6
TRIM17
TRIM21
TRIM25
TRIM46
TRIM5
TRIM54
TRIM63
TRIM74
UBE2S
UCHL1
UCHL3
USP14
USP2
USP20
USP21
USP28
USP33
USP51
USP8
YOD1
11 interacting genes:
BRCA1
LRSAM1
MGRN1
RBX1
REL
RNF32
TSG101
UBE2U
USP15
USP2
USP32
Entrez ID
9958
378108
HPRD ID
05293
15567
Ensembl ID
ENSG00000135655
ENSG00000155428
Uniprot IDs
Q9Y4E8
Q86UV6
PDB IDs
1W6V
3LMN
3PPA
3PV1
3T9L
4A3O
4A3P
5JJW
6CPM
6CRN
6DJ9
6GH9
6GHA
6ML1
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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