USP7 and MYD88

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		USP7	MYD88
Description		ubiquitin specific peptidase 7	MYD88 innate immune signal transduction adaptor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol Nuclear Body PML Body Protein-containing Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Protein-containing Complex
	Molecular Function	P53 Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity	Toll Binding Death Receptor Binding Interleukin-1 Receptor Binding Protein Binding Toll-like Receptor Binding Identical Protein Binding Protein Self-association TIR Domain Binding
	Biological Process	Regulation Of Gluconeogenesis Transcription-coupled Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Maintenance Of DNA Methylation Viral Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Protein Stabilization Regulation Of DNA-binding Transcription Factor Activity Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of DNA Demethylation Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi	Toll-like Receptor Signaling Pathway Response To Molecule Of Fungal Origin MyD88-dependent Toll-like Receptor Signaling Pathway Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway JNK Cascade Toll Signaling Pathway Response To Virus Induced Systemic Resistance Positive Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Peptidoglycan Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 9 Signaling Pathway Defense Response To Bacterium Defense Response To Protozoan Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Establishment Of Endothelial Intestinal Barrier Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Neutrophil Migration Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Ub-specific processing proteases Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Regulation of PTEN localization	ER-Phagosome pathway PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane RIP-mediated NFkB activation via ZBP1 p75NTR recruits signalling complexes p75NTR recruits signalling complexes DEx/H-box helicases activate type I IFN and inflammatory cytokines production MyD88 deficiency (TLR2/4) MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Chronotype ( 30696823) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)	Gut microbiota (bacterial taxa) ( 27723756) Mean corpuscular hemoglobin concentration ( 29403010)
Interacting Genes		103 interacting genes: ABRAXAS2 ACD ANKS1A ANXA1 ARNT2 ATXN1 AXIN1 BCOR BEND5 CBX8 CLSPN CREB3L3 CRY1 CSNK2A1 DAXX DCTPP1 DNAJA3 DNMT3A ERCC6 EWSR1 FOXN2 GATA1 H2AC20 H2BU1 HECW1 HERPUD1 HIF1A HTRA2 HUWE1 IFNAR1 KAT5 KDM1A KLHL8 LINC02582 MAGEE1 MAL MARCHF7 MCMBP MDM2 MDM4 MYC MYD88 NECAB2 NOTCH1 OTUD4 PCGF2 PEG3 PEPD PHF8 PHLDB2 PICK1 PLA2G2A PLEKHO1 PLK1 PPARG PPL PSMD4 PTEN RAD18 RADIL RARA RB1 RBCK1 RELA RFFL RNF168 RNF220 SIRT7 SMAD3 SNCA SUMO2 SYVN1 TANK TBCB TFIP11 TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBA52 UBC UBE2D3 UBE2E1 UBE2S USP21 USP28 VCP WWP2 XPC ZMYND8 ZNF423 ZNF76	43 interacting genes: BTK CD93 CISH FADD FLII IKBKG IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 NTAQ1 PELI2 PFKL POLR1C PRDX1 RAC1 RNF4 SARM1 SIAH2 SMAD3 SPOP SPOPL STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7 ZNF35
Entrez ID		7874	4615
HPRD ID		03950	03703
Ensembl ID		ENSG00000187555	ENSG00000172936
Uniprot IDs		B7Z855 B7ZAX6 Q6U8A4 Q93009	A0A0A0MSI9 A0A3B3ITY3 A0A3F2YP85 Q99836
PDB IDs		1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ 4KG9 4M5W 4M5X 4PYZ 4WPH 4WPI 4YOC 4YSI 4Z96 4Z97 5C56 5C6D 5FWI 5GG4 5J7T 5JTJ 5JTV 5KYB 5KYC 5KYD 5KYE 5KYF 5N9R 5N9T 5NGE 5NGF 5UQV 5UQX 5VS6 5VSB 5VSK 5WHC 6F5H 6P5L 6VN2 6VN3 6VN4 6VN5 6VN6 7CM2	2JS7 2Z5V 3MOP 4DOM 4EO7 6I3N
Enriched GO Terms of Interacting Partners?
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