USP7 and PTEN

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, pull down)

		USP7	PTEN
Description		ubiquitin specific peptidase 7	phosphatase and tensin homolog
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol Nuclear Body PML Body Protein-containing Complex	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Apical Plasma Membrane PML Body Myelin Sheath Adaxonal Region Cell Projection Neuron Projection Dendritic Spine Schmidt-Lanterman Incisure Postsynaptic Membrane Postsynaptic Cytosol
	Molecular Function	P53 Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity	Phosphatidylinositol-3-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Lipid Binding Anaphase-promoting Complex Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Enzyme Binding PDZ Domain Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity Ubiquitin-specific Protease Binding Protein Tyrosine Kinase Binding
	Biological Process	Regulation Of Gluconeogenesis Transcription-coupled Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Maintenance Of DNA Methylation Viral Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Protein Stabilization Regulation Of DNA-binding Transcription Factor Activity Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of DNA Demethylation Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi	Angiogenesis Negative Regulation Of Protein Phosphorylation Regulation Of B Cell Apoptotic Process Transcription Initiation From RNA Polymerase II Promoter Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Apoptotic Process Neuron-neuron Synaptic Transmission Synapse Assembly Central Nervous System Development Heart Development Aging Response To Nutrient Learning Or Memory Memory Locomotory Behavior Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Glucose Response To Zinc Ion Positive Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Dephosphorylation Cell Migration Protein Deubiquitination Dentate Gyrus Development Central Nervous System Neuron Axonogenesis Negative Regulation Of Cell Migration Adult Behavior Negative Regulation Of Myelination Regulation Of Protein Stability Regulation Of Synaptic Transmission, GABAergic Central Nervous System Myelin Maintenance Response To Estradiol Regulation Of Cellular Component Size Cellular Response To Insulin Stimulus Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Peptidyl-serine Phosphorylation Response To ATP Multicellular Organismal Response To Stress Social Behavior Peptidyl-tyrosine Dephosphorylation Response To Drug Maternal Behavior Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Endothelial Cell Migration Inositol Phosphate Metabolic Process Cellular Response To Leptin Stimulus Locomotor Rhythm Positive Regulation Of Neuron Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Size Negative Regulation Of Organ Growth Response To Arsenic-containing Substance Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Cardiac Muscle Tissue Development Forebrain Morphogenesis Brain Morphogenesis Cell Motility Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Phagocytosis Negative Regulation Of Axonogenesis Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Keratinocyte Migration Negative Regulation Of Focal Adhesion Assembly Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Rhythmic Synaptic Transmission Negative Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Synapse Maturation Prepulse Inhibition Male Mating Behavior Long-term Synaptic Potentiation Long-term Synaptic Depression Prostate Gland Growth Dendritic Spine Morphogenesis Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Electrical Stimulus Cellular Response To Ethanol Cellular Response To Hypoxia Negative Regulation Of Ribosome Biogenesis Negative Regulation Of Cell Aging Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Postsynaptic Density Assembly Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Negative Regulation Of Synaptic Vesicle Clustering
Pathways		Ub-specific processing proteases Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Regulation of PTEN localization	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Negative regulation of the PI3K/AKT network Downstream TCR signaling TP53 Regulates Metabolic Genes PTEN Loss of Function in Cancer Ub-specific processing proteases Ovarian tumor domain proteases Regulation of PTEN mRNA translation Regulation of PTEN localization Regulation of PTEN stability and activity Transcriptional Regulation by MECP2
Drugs			Phosphatidylethanolamine
Diseases			Vulvar cancer Prostate cancer Endometrial Cancer Glioma Small cell lung cancer Breast cancer Hepatocellular carcinoma Malignant melanoma
GWAS		Chronotype ( 30696823) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)	Ambidextrousness ( 32989287) Birth weight ( 31043758) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 31562340) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mercury levels ( 26025379) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 32888494) Plateletcrit ( 32888494) Psoriasis ( 28537254) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Sum eosinophil basophil counts ( 27863252) Thyroid stimulating hormone levels ( 30367059 32769997) Type 2 diabetes ( 24509480 32499647) Type 2 diabetes (adjusted for BMI) ( 30297969) White blood cell count ( 32888494) White blood cell count (basophil) ( 29403010)
Interacting Genes		103 interacting genes: ABRAXAS2 ACD ANKS1A ANXA1 ARNT2 ATXN1 AXIN1 BCOR BEND5 CBX8 CLSPN CREB3L3 CRY1 CSNK2A1 DAXX DCTPP1 DNAJA3 DNMT3A ERCC6 EWSR1 FOXN2 GATA1 H2AC20 H2BU1 HECW1 HERPUD1 HIF1A HTRA2 HUWE1 IFNAR1 KAT5 KDM1A KLHL8 LINC02582 MAGEE1 MAL MARCHF7 MCMBP MDM2 MDM4 MYC MYD88 NECAB2 NOTCH1 OTUD4 PCGF2 PEG3 PEPD PHF8 PHLDB2 PICK1 PLA2G2A PLEKHO1 PLK1 PPARG PPL PSMD4 PTEN RAD18 RADIL RARA RB1 RBCK1 RELA RFFL RNF168 RNF220 SIRT7 SMAD3 SNCA SUMO2 SYVN1 TANK TBCB TFIP11 TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBA52 UBC UBE2D3 UBE2E1 UBE2S USP21 USP28 VCP WWP2 XPC ZMYND8 ZNF423 ZNF76	356 interacting genes: AATK ABCF2 ACTL6A ADAR AFP AKAP12 AKT1 ALYREF AMOT ANAPC10 ANAPC7 ANG ANP32B ANP32E ANXA2 AR ARF4 ARMCX3 ASCC3 ATP5F1A ATP5F1C BCAR1 BEX1 BUB3 CAD CALM1 CAMK2G CAV1 CCDC180 CCDC47 CCND2 CCT2 CCT3 CCT4 CCT6A CCT8 CDC27 CEP170 CEP97 CFL1 CHD4 CHGB CMAS COPA COPB1 COPS6 CSNK1A1 CSNK2A1 CSNK2A2 CUL4B CXCL1 DAP3 DAXX DBN1 DCAF11 DCAF13 DDB1 DDOST DDX1 DDX21 DDX24 DDX47 DDX50 DHX15 DHX9 DLC1 DLG1 DNAJA1 DNAJA2 DNAJA3 DNAJB6 DNAJC10 DPM1 DRG1 DSP EEF2 EIF4E EIF6 EPHA2 EPRS1 ERBB3 ESR1 EXOSC1 EXOSC2 EXOSC4 EXOSC5 EXOSC7 FARSA FARSB FASN FBL FBXW11 FOXK1 FUBP3 GEMIN4 GNAI1 GNAI2 GNB4 GNL3 GPC4 GSTM2 GTF3C2 GTF3C3 GTF3C5 H2AC4 HADHA HBA1 HNRNPA1 HNRNPA3 HNRNPAB HNRNPUL1 HSD17B1 HSD17B10 HSP90AB1 HSP90B1 HSPA4 HSPA4L HSPA8 HSPBP1 HSPD1 HSPH1 IL24 ILF2 ILF3 INS IPO5 IPO7 IRS4 ITPRID2 JUP KBTBD4 KDM1A KPNB1 LATS1 LGALS1 LIMA1 LINC00839 LINC01198 LINC02023 LMNB1 LRPPRC LTV1 MAGED2 MAGI2 MAGI3 MAP2K3 MAST1 MAST2 MAST3 MATR3 MCM2 MCM3 MCM5 MCRS1 MDN1 METTL26 MKI67 MME MPRIP MRPS22 MRPS23 MRPS27 MRPS28 MRPS7 MRPS9 MSH6 MTHFD2 MVP MYBBP1A MYC MYH10 MYL12A MYO1B MYO1C MYO1D MYOF NACA NCBP1 NCF1 NDFIP1 NGB NOP56 NOP58 NPM3 NUMB OSGIN1 OTUD3 PBK PBRM1 PCNA PDGFRB PELO PELP1 PHB PHB2 PKM PLEC PLK1 POLDIP2 POLR1A POLR2A POLR2B POLR2H POP1 PPL PPP1CA PPP2CA PRDX1 PRDX3 PRKDC PRPF19 PRPF8 PSMD3 PSMD4 PSMD7 PTDSS1 PTK2 PTK7 PURA PXN QPCTL RAD21 RANBP2 RANGAP1 RBBP5 RBM4 RCC2 RCN1 RFC3 RFC4 RFC5 RING1 RPL10 RPL10A RPL12 RPL13 RPL13A RPL14 RPL17 RPL18A RPL21 RPL22 RPL22L1 RPL23 RPL23A RPL27 RPL27A RPL28 RPL30 RPL31 RPL32 RPL34 RPL36 RPL38 RPL7 RPLP0 RPLP2 RPN2 RPP30 RPP38 RPP40 RPS11 RPS13 RPS15 RPS15A RPS17 RPS2 RPS20 RPS23 RPS25 RPS26 RPS27 RPS27A RPS3 RPS4X RPS5 RPS6 RPS9 RSL1D1 S100A8 S100A9 SDC1 SDC4 SDCBP SEC61A1 SET SETX SIN3A SIRT4 SKP1 SLC25A1 SLC25A13 SLC25A3 SLC25A5 SLC9A3R1 SLC9A3R2 SMARCA4 SMARCA5 SMC2 SMC4 SMCHD1 SNAI1 SNRNP200 SNRPA1 SNRPB2 SNRPD1 SNTB2 SNX27 SPTAN1 SPTBN1 SRP14 SSB SSR4 SSRP1 STAG2 STK11 STRAP STUB1 SUDS3 SUGP2 TCF25 TCP1 TECR TERF2IP THOC2 THOC3 THOC6 TMEFF1 TNKS TNKS2 TP53 TRIM28 TRMO TUBA1B TUBB TUBB4B TUFM TWIST1 TXN U2AF1 UBE2D3 UBE2I UBE2L3 UBE2S UPF1 USP7 USP9X UTP14A UTRN XRCC5 XRCC6 YAP1 YES1 YTHDC2 YTHDF2 ZNF326
Entrez ID		7874	5728
HPRD ID		03950	03431
Ensembl ID		ENSG00000187555	ENSG00000171862
Uniprot IDs		B7Z855 B7ZAX6 Q6U8A4 Q93009	F6KD01 P60484
PDB IDs		1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ 4KG9 4M5W 4M5X 4PYZ 4WPH 4WPI 4YOC 4YSI 4Z96 4Z97 5C56 5C6D 5FWI 5GG4 5J7T 5JTJ 5JTV 5KYB 5KYC 5KYD 5KYE 5KYF 5N9R 5N9T 5NGE 5NGF 5UQV 5UQX 5VS6 5VSB 5VSK 5WHC 6F5H 6P5L 6VN2 6VN3 6VN4 6VN5 6VN6 7CM2	1D5R 2KYL 4O1V 5BUG 5BZX 5BZZ
Enriched GO Terms of Interacting Partners?
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