UCHL3 and FOXM1

Data Source:
BioGRID (enzymatic study)

		UCHL3	FOXM1
Description		ubiquitin C-terminal hydrolase L3	forkhead box M1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity NEDD8-specific Protease Activity Ubiquitin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Protein Catabolic Process Post-translational Protein Modification	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Positive Regulation Of Cell Population Proliferation Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Cell Population Proliferation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Cell Cycle Regulation Of Cell Cycle Arrest Negative Regulation Of Cell Aging Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Double-strand Break Repair
Pathways		UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation	Polo-like kinase mediated events Cyclin A/B1/B2 associated events during G2/M transition
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)	Height ( 31562340)
Interacting Genes		20 interacting genes: ATM ATXN7L3 CDH1 FOXM1 LONRF1 NEDD8 NSG2 PJA1 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5	18 interacting genes: BANP CCNE1 CDK1 CDK2 CDK4 CDK6 CHEK2 CREBBP DCAF1 OS9 OTUB1 SIRT1 STAT3 SUMO1 UBE2I UCHL3 USP21 ZBTB3
Entrez ID		7347	2305
HPRD ID		04367	03823
Ensembl ID		ENSG00000118939	ENSG00000111206
Uniprot IDs		A0A087WTB8 A0A140VJZ4 P15374	A0A0D9SFF0 A0A2P9DTZ1 A0A2P9DTZ8 A8K591 Q08050 Q53Y49
PDB IDs		1UCH 1XD3 6ISU 6QML	3G73
Enriched GO Terms of Interacting Partners?
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