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NCS1 and GRK2
Data Source:
HPRD
(in vivo)
NCS1
GRK2
Description
neuronal calcium sensor 1
G protein-coupled receptor kinase 2
Image
GO Annotations
Cellular Component
Cytoplasm
Golgi Apparatus
Plasma Membrane
Postsynaptic Density
Dendrite
Dense Core Granule
Intracellular Membrane-bounded Organelle
Calyx Of Held
Perinuclear Region Of Cytoplasm
Glutamatergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
Cytoplasm
Cytosol
Plasma Membrane
Cilium
Membrane
Synapse
Molecular Function
Magnesium Ion Binding
Voltage-gated Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Protein Kinase Binding
Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
Protein Kinase Activity
G Protein-coupled Receptor Kinase Activity
Protein Binding
ATP Binding
Alpha-2A Adrenergic Receptor Binding
Edg-2 Lysophosphatidic Acid Receptor Binding
Beta-adrenergic Receptor Kinase Activity
Biological Process
Regulation Of Neuron Projection Development
Positive Regulation Of Exocytosis
Phosphatidylinositol-mediated Signaling
Calcium Ion Transmembrane Transport
Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Regulation Of Synaptic Vesicle Exocytosis
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of The Force Of Heart Contraction By Chemical Signal
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Tachykinin Receptor Signaling Pathway
Heart Development
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Viral Genome Replication
Receptor Internalization
Positive Regulation Of Catecholamine Secretion
Negative Regulation Of Striated Muscle Contraction
Viral Entry Into Host Cell
Cardiac Muscle Contraction
Negative Regulation Of Relaxation Of Smooth Muscle
Pathways
Calmodulin induced events
G alpha (q) signalling events
G alpha (s) signalling events
Activation of SMO
Activation of SMO
Cargo recognition for clathrin-mediated endocytosis
Drugs
Calcium citrate
Calcium Phosphate
Calcium phosphate dihydrate
ATP
Diseases
GWAS
Alzheimer's disease (cognitive decline) (
23535033
)
Tuberculosis (
30713548
)
Interacting Genes
27 interacting genes:
C1QTNF2
CDSN
CEP89
CREM
CTAG1A
CTAG1B
DRD2
DRD3
DRD5
DTX2
FZD7
GRK2
IL1RAPL1
KCND2
LY6G6D
MEOX2
MIEF2
NBL1
OXER1
PI4KB
PRDM4
RNASEH1
SFTPA2
SIGLEC9
SPP1
SPRED2
ZC3H10
51 interacting genes:
ADRA2A
ADRB2
AGTR1
AKAP12
ARRB1
ARRB2
BDKRB2
CAPN2
CAV1
CCR4
CCR5
CSNK2B
EGF
EGFR
EPHA2
ERBB2
FBXO25
FPR1
FSHR
GIT1
GIT2
GNA15
GNAQ
GNB2
GNB3
GRM1
HDAC6
KCNIP3
MAPK3
MC4R
MDM2
NCS1
OPRD1
PDC
PDCL
PDE6G
PEBP1
PIK3CG
PLCB1
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
RASGRF1
RCVRN
RHO
RPLP2
SNCA
SRC
TPM2
Entrez ID
23413
156
HPRD ID
04500
00182
Ensembl ID
ENSG00000107130
ENSG00000173020
Uniprot IDs
A0A024R8B2
P62166
A0A0S2Z392
P25098
PDB IDs
1G8I
2LCP
4GUK
5O9S
6QI4
1BAK
3CIK
3KRW
3KRX
3V5W
4MK0
4PNK
5HE1
5UKK
5UKL
5UUU
5UVC
5WG3
5WG4
5WG5
6C2Y
6U7C
7K7L
7K7Z
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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