GRK2 and AKAP12

Data Source:
HPRD (in vivo, in vitro)

		GRK2	AKAP12
Description		G protein-coupled receptor kinase 2	A-kinase anchoring protein 12
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Synapse	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Neuronal Cell Body Schaffer Collateral - CA1 Synapse
	Molecular Function	Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity	Protein Binding Calmodulin Binding Adenylate Cyclase Binding Protein Kinase A Binding
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Viral Entry Into Host Cell Cardiac Muscle Contraction Negative Regulation Of Relaxation Of Smooth Muscle	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Protein Kinase A Signaling Positive Regulation Of Protein Kinase A Signaling Response To Lipopolysaccharide Hepatic Stellate Cell Activation Negative Regulation Of Vascular Permeability Modulation Of Chemical Synaptic Transmission Response To Electrical Stimulus Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Hepatic Stellate Cell Migration Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Regulation Of Protein Kinase C Signaling Positive Regulation Of Oligodendrocyte Apoptotic Process
Pathways		Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis
Drugs		ATP
Diseases
GWAS			Alzheimer's disease progression score ( 29860282) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Chronic myeloid leukemia ( 21540461) Coronary artery disease ( 29212778) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Delirium ( 29631748) Heel bone mineral density ( 30598549) Nevus count or cutaneous melanoma ( 32341527) Refractive error ( 32231278) Type 2 diabetes ( 25760438) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		51 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 ARRB2 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 ERBB2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB2 GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2	8 interacting genes: ADRB2 EGFR ERBB2 FHL1 GRK2 PRKAR2A PRKCA PTEN
Entrez ID		156	9590
HPRD ID		00182	05263
Ensembl ID		ENSG00000173020	ENSG00000131016
Uniprot IDs		A0A0S2Z392 P25098	Q02952 Q86TJ9
PDB IDs		1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y 6U7C 7K7L 7K7Z
Enriched GO Terms of Interacting Partners?
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