Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
GRK2 and AKAP12
Data Source:
HPRD
(in vivo, in vitro)
GRK2
AKAP12
Description
G protein-coupled receptor kinase 2
A-kinase anchoring protein 12
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cilium
Membrane
Synapse
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Cell Cortex
Neuronal Cell Body
Schaffer Collateral - CA1 Synapse
Molecular Function
Protein Kinase Activity
G Protein-coupled Receptor Kinase Activity
Protein Binding
ATP Binding
Alpha-2A Adrenergic Receptor Binding
Edg-2 Lysophosphatidic Acid Receptor Binding
Beta-adrenergic Receptor Kinase Activity
Protein Binding
Calmodulin Binding
Adenylate Cyclase Binding
Protein Kinase A Binding
Biological Process
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of The Force Of Heart Contraction By Chemical Signal
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Tachykinin Receptor Signaling Pathway
Heart Development
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Viral Genome Replication
Receptor Internalization
Positive Regulation Of Catecholamine Secretion
Negative Regulation Of Striated Muscle Contraction
Viral Entry Into Host Cell
Cardiac Muscle Contraction
Negative Regulation Of Relaxation Of Smooth Muscle
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Regulation Of Protein Kinase A Signaling
Positive Regulation Of Protein Kinase A Signaling
Response To Lipopolysaccharide
Hepatic Stellate Cell Activation
Negative Regulation Of Vascular Permeability
Modulation Of Chemical Synaptic Transmission
Response To Electrical Stimulus
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Hepatic Stellate Cell Migration
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Regulation Of Protein Kinase C Signaling
Positive Regulation Of Oligodendrocyte Apoptotic Process
Pathways
Calmodulin induced events
G alpha (q) signalling events
G alpha (s) signalling events
Activation of SMO
Activation of SMO
Cargo recognition for clathrin-mediated endocytosis
Drugs
ATP
Diseases
GWAS
Alzheimer's disease progression score (
29860282
)
Blond vs. brown/black hair color (
30531825
)
Brown vs. black hair color (
30531825
)
Chronic myeloid leukemia (
21540461
)
Coronary artery disease (
29212778
)
Cutaneous malignant melanoma (
32341527
)
Cutaneous melanoma or hair colour (
32341527
)
Delirium (
29631748
)
Heel bone mineral density (
30598549
)
Nevus count or cutaneous melanoma (
32341527
)
Refractive error (
32231278
)
Type 2 diabetes (
25760438
)
Youthful appearance (self-reported) (
32339537
)
Interacting Genes
51 interacting genes:
ADRA2A
ADRB2
AGTR1
AKAP12
ARRB1
ARRB2
BDKRB2
CAPN2
CAV1
CCR4
CCR5
CSNK2B
EGF
EGFR
EPHA2
ERBB2
FBXO25
FPR1
FSHR
GIT1
GIT2
GNA15
GNAQ
GNB2
GNB3
GRM1
HDAC6
KCNIP3
MAPK3
MC4R
MDM2
NCS1
OPRD1
PDC
PDCL
PDE6G
PEBP1
PIK3CG
PLCB1
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
RASGRF1
RCVRN
RHO
RPLP2
SNCA
SRC
TPM2
8 interacting genes:
ADRB2
EGFR
ERBB2
FHL1
GRK2
PRKAR2A
PRKCA
PTEN
Entrez ID
156
9590
HPRD ID
00182
05263
Ensembl ID
ENSG00000173020
ENSG00000131016
Uniprot IDs
A0A0S2Z392
P25098
Q02952
Q86TJ9
PDB IDs
1BAK
3CIK
3KRW
3KRX
3V5W
4MK0
4PNK
5HE1
5UKK
5UKL
5UUU
5UVC
5WG3
5WG4
5WG5
6C2Y
6U7C
7K7L
7K7Z
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?