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GRK2 and GNB3
Data Source:
BioGRID
(enzymatic study)
GRK2
GNB3
Description
G protein-coupled receptor kinase 2
G protein subunit beta 3
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cilium
Membrane
Synapse
Cytoplasm
Cytosol
Heterotrimeric G-protein Complex
Plasma Membrane
Dendrite
Cell Body
Extracellular Exosome
Molecular Function
Protein Kinase Activity
G Protein-coupled Receptor Kinase Activity
Protein Binding
ATP Binding
Alpha-2A Adrenergic Receptor Binding
Edg-2 Lysophosphatidic Acid Receptor Binding
Beta-adrenergic Receptor Kinase Activity
GTPase Activity
Protein Binding
Spectrin Binding
G-protein Gamma-subunit Binding
GTPase Binding
Biological Process
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of The Force Of Heart Contraction By Chemical Signal
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Tachykinin Receptor Signaling Pathway
Heart Development
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Viral Genome Replication
Receptor Internalization
Positive Regulation Of Catecholamine Secretion
Negative Regulation Of Striated Muscle Contraction
Viral Entry Into Host Cell
Cardiac Muscle Contraction
Negative Regulation Of Relaxation Of Smooth Muscle
Protein Folding
Cell Volume Homeostasis
G Protein-coupled Receptor Signaling Pathway
Regulation Of Blood Pressure
Regulation Of Gene Expression
Regulation Of Glucose Metabolic Process
Regulation Of Hormone Metabolic Process
Regulation Of Fat Cell Differentiation
Regulation Of Feeding Behavior
Regulation Of Cholesterol Metabolic Process
Regulation Of Triglyceride Metabolic Process
Regulation Of Locomotion Involved In Locomotory Behavior
Regulation Of Phospholipid Metabolic Process
Pathways
Calmodulin induced events
G alpha (q) signalling events
G alpha (s) signalling events
Activation of SMO
Activation of SMO
Cargo recognition for clathrin-mediated endocytosis
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G beta:gamma signalling through BTK
G beta:gamma signalling through CDC42
Extra-nuclear estrogen signaling
ADORA2B mediated anti-inflammatory cytokines production
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
ATP
Diseases
GWAS
Central retinal vein equivalent (
26567291
)
High myopia (
31816047
)
Macular thickness (
30535121
)
Myopia (
27182965
)
Refractive error (
32231278
)
Response to Vitamin E supplementation (
22437554
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Interacting Genes
51 interacting genes:
ADRA2A
ADRB2
AGTR1
AKAP12
ARRB1
ARRB2
BDKRB2
CAPN2
CAV1
CCR4
CCR5
CSNK2B
EGF
EGFR
EPHA2
ERBB2
FBXO25
FPR1
FSHR
GIT1
GIT2
GNA15
GNAQ
GNB2
GNB3
GRM1
HDAC6
KCNIP3
MAPK3
MC4R
MDM2
NCS1
OPRD1
PDC
PDCL
PDE6G
PEBP1
PIK3CG
PLCB1
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
RASGRF1
RCVRN
RHO
RPLP2
SNCA
SRC
TPM2
13 interacting genes:
CIDEB
GNG10
GNG12
GNG13
GNG2
GNG3
GNG4
GNG5
GNG7
GNG8
GRK2
RASD2
TGFBR1
Entrez ID
156
2784
HPRD ID
00182
00743
Ensembl ID
ENSG00000173020
ENSG00000111664
Uniprot IDs
A0A0S2Z392
P25098
E9PCP0
F1T0G5
P16520
PDB IDs
1BAK
3CIK
3KRW
3KRX
3V5W
4MK0
4PNK
5HE1
5UKK
5UKL
5UUU
5UVC
5WG3
5WG4
5WG5
6C2Y
6U7C
7K7L
7K7Z
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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