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GRK2 and CAPN2
Data Source:
HPRD
(in vitro, in vivo)
GRK2
CAPN2
Description
G protein-coupled receptor kinase 2
calpain 2
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cilium
Membrane
Synapse
Chromatin
Nucleus
Cytoplasm
Mitochondrial Intermembrane Space
Lysosome
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Plasma Membrane
Focal Adhesion
External Side Of Plasma Membrane
Dendrite
Cortical Actin Cytoskeleton
Pseudopodium
Neuronal Cell Body
Membrane Raft
Extracellular Exosome
Perinuclear Endoplasmic Reticulum
Molecular Function
Protein Kinase Activity
G Protein-coupled Receptor Kinase Activity
Protein Binding
ATP Binding
Alpha-2A Adrenergic Receptor Binding
Edg-2 Lysophosphatidic Acid Receptor Binding
Beta-adrenergic Receptor Kinase Activity
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Cytoskeletal Protein Binding
Cysteine-type Peptidase Activity
Enzyme Binding
Protein-containing Complex Binding
Biological Process
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of The Force Of Heart Contraction By Chemical Signal
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Tachykinin Receptor Signaling Pathway
Heart Development
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Viral Genome Replication
Receptor Internalization
Positive Regulation Of Catecholamine Secretion
Negative Regulation Of Striated Muscle Contraction
Viral Entry Into Host Cell
Cardiac Muscle Contraction
Negative Regulation Of Relaxation Of Smooth Muscle
Response To Hypoxia
Blastocyst Development
Proteolysis
Myoblast Fusion
Female Pregnancy
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Extracellular Matrix Disassembly
Regulation Of Interleukin-6 Production
Cellular Response To Interferon-beta
Response To Hydrogen Peroxide
Behavioral Response To Pain
Regulation Of Cytoskeleton Organization
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Amino Acid Stimulus
Positive Regulation Of Neuron Death
Positive Regulation Of Myoblast Fusion
Positive Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways
Calmodulin induced events
G alpha (q) signalling events
G alpha (s) signalling events
Activation of SMO
Activation of SMO
Cargo recognition for clathrin-mediated endocytosis
Degradation of the extracellular matrix
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
ATP
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Carotenoid levels (alpha-carotene) (
28002826
)
Febrile seizures (MMR vaccine-related) (
25344690
)
Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) (
33208821
)
Waist circumference (
31170924
)
Interacting Genes
51 interacting genes:
ADRA2A
ADRB2
AGTR1
AKAP12
ARRB1
ARRB2
BDKRB2
CAPN2
CAV1
CCR4
CCR5
CSNK2B
EGF
EGFR
EPHA2
ERBB2
FBXO25
FPR1
FSHR
GIT1
GIT2
GNA15
GNAQ
GNB2
GNB3
GRM1
HDAC6
KCNIP3
MAPK3
MC4R
MDM2
NCS1
OPRD1
PDC
PDCL
PDE6G
PEBP1
PIK3CG
PLCB1
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
RASGRF1
RCVRN
RHO
RPLP2
SNCA
SRC
TPM2
23 interacting genes:
ATG5
ATXN3
BCL2
BID
CAPNS1
CAPNS2
CASP9
CDK5R1
DUX4
F2RL1
GAS2
GRK2
KNG1
MAPK1
MAPT
MTDH
NFKBIA
NMT1
PBXIP1
PTPN1
PTPRN
TNS1
ZFYVE21
Entrez ID
156
824
HPRD ID
00182
00254
Ensembl ID
ENSG00000173020
ENSG00000162909
Uniprot IDs
A0A0S2Z392
P25098
B4DN77
P17655
Q59EF6
PDB IDs
1BAK
3CIK
3KRW
3KRX
3V5W
4MK0
4PNK
5HE1
5UKK
5UKL
5UUU
5UVC
5WG3
5WG4
5WG5
6C2Y
6U7C
7K7L
7K7Z
1KFU
1KFX
2NQA
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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