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GRK2 and EGF
Data Source:
HPRD
(in vivo)
GRK2
EGF
Description
G protein-coupled receptor kinase 2
epidermal growth factor
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cilium
Membrane
Synapse
Extracellular Region
Extracellular Space
Lysosomal Membrane
Plasma Membrane
Integral Component Of Membrane
Clathrin-coated Vesicle Membrane
Platelet Alpha Granule Lumen
Extracellular Exosome
Molecular Function
Protein Kinase Activity
G Protein-coupled Receptor Kinase Activity
Protein Binding
ATP Binding
Alpha-2A Adrenergic Receptor Binding
Edg-2 Lysophosphatidic Acid Receptor Binding
Beta-adrenergic Receptor Kinase Activity
Guanyl-nucleotide Exchange Factor Activity
Epidermal Growth Factor Receptor Binding
Calcium Ion Binding
Protein Binding
Growth Factor Activity
Transmembrane Receptor Protein Tyrosine Kinase Activator Activity
Biological Process
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of The Force Of Heart Contraction By Chemical Signal
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Tachykinin Receptor Signaling Pathway
Heart Development
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Viral Genome Replication
Receptor Internalization
Positive Regulation Of Catecholamine Secretion
Negative Regulation Of Striated Muscle Contraction
Viral Entry Into Host Cell
Cardiac Muscle Contraction
Negative Regulation Of Relaxation Of Smooth Muscle
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Receptor Internalization
Platelet Degranulation
Signal Transduction
Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation
Positive Regulation Of Cell Migration
Epidermal Growth Factor Receptor Signaling Pathway Via MAPK Cascade
ERBB2 Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Positive Regulation Of DNA Binding
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of DNA Replication
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription, DNA-templated
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Branching Morphogenesis Of An Epithelial Tube
Negative Regulation Of Secretion
Positive Regulation Of Protein Kinase B Signaling
Mammary Gland Alveolus Development
Membrane Organization
ERK1 And ERK2 Cascade
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Calcium Ion Import
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Hyaluronan Biosynthetic Process
Negative Regulation Of ERBB Signaling Pathway
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Epithelial Tube Formation
Regulation Of Protein Localization To Cell Surface
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cell Motility
Pathways
Calmodulin induced events
G alpha (q) signalling events
G alpha (s) signalling events
Activation of SMO
Activation of SMO
Cargo recognition for clathrin-mediated endocytosis
Platelet degranulation
Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Signaling by ERBB4
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
Signaling by EGFR
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR interacts with phospholipase C-gamma
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by EGFRvIII
Inhibition of Signaling by Overexpressed EGFR
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
Extra-nuclear estrogen signaling
NOTCH3 Activation and Transmission of Signal to the Nucleus
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drugs
ATP
Sucralfate
Alpha-Aminobutyric Acid
Cholecystokinin
Tesevatinib
Diseases
Gastric cancer
GWAS
Albumin-globulin ratio (
29403010
)
Blood protein levels (
30072576
29875488
)
Hair morphology (
19896111
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Lymphocyte counts (
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
29403010
)
Mean spheric corpuscular volume (
32888494
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Non-albumin protein levels (
29403010
)
Platelet count (
29403010
32888494
27863252
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Waist-to-hip ratio adjusted for BMI (
28552196
)
Interacting Genes
51 interacting genes:
ADRA2A
ADRB2
AGTR1
AKAP12
ARRB1
ARRB2
BDKRB2
CAPN2
CAV1
CCR4
CCR5
CSNK2B
EGF
EGFR
EPHA2
ERBB2
FBXO25
FPR1
FSHR
GIT1
GIT2
GNA15
GNAQ
GNB2
GNB3
GRM1
HDAC6
KCNIP3
MAPK3
MC4R
MDM2
NCS1
OPRD1
PDC
PDCL
PDE6G
PEBP1
PIK3CG
PLCB1
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
RASGRF1
RCVRN
RHO
RPLP2
SNCA
SRC
TPM2
14 interacting genes:
ADAM12
CPM
DUSP3
EGFR
ERBB2
ERBB3
GRB2
GRK2
LMNA
MGST1
NRG1
PIK3R1
PIK3R2
VTN
Entrez ID
156
1950
HPRD ID
00182
00578
Ensembl ID
ENSG00000173020
ENSG00000138798
Uniprot IDs
A0A0S2Z392
P25098
P01133
PDB IDs
1BAK
3CIK
3KRW
3KRX
3V5W
4MK0
4PNK
5HE1
5UKK
5UKL
5UUU
5UVC
5WG3
5WG4
5WG5
6C2Y
6U7C
7K7L
7K7Z
1IVO
1JL9
1NQL
1P9J
2KV4
3NJP
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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