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GRK2 and RPLP2
Data Source:
HPRD
(in vitro, in vivo)
GRK2
RPLP2
Description
G protein-coupled receptor kinase 2
ribosomal protein lateral stalk subunit P2
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cilium
Membrane
Synapse
Cytosol
Focal Adhesion
Membrane
Cytosolic Large Ribosomal Subunit
Extracellular Exosome
Molecular Function
Protein Kinase Activity
G Protein-coupled Receptor Kinase Activity
Protein Binding
ATP Binding
Alpha-2A Adrenergic Receptor Binding
Edg-2 Lysophosphatidic Acid Receptor Binding
Beta-adrenergic Receptor Kinase Activity
Structural Constituent Of Ribosome
Protein Binding
Biological Process
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of The Force Of Heart Contraction By Chemical Signal
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Tachykinin Receptor Signaling Pathway
Heart Development
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Viral Genome Replication
Receptor Internalization
Positive Regulation Of Catecholamine Secretion
Negative Regulation Of Striated Muscle Contraction
Viral Entry Into Host Cell
Cardiac Muscle Contraction
Negative Regulation Of Relaxation Of Smooth Muscle
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Cytoplasmic Translational Elongation
Translation
Translational Initiation
SRP-dependent Cotranslational Protein Targeting To Membrane
Viral Transcription
Pathways
Calmodulin induced events
G alpha (q) signalling events
G alpha (s) signalling events
Activation of SMO
Activation of SMO
Cargo recognition for clathrin-mediated endocytosis
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
ATP
Diseases
GWAS
Intraocular pressure (
29785010
)
Interacting Genes
51 interacting genes:
ADRA2A
ADRB2
AGTR1
AKAP12
ARRB1
ARRB2
BDKRB2
CAPN2
CAV1
CCR4
CCR5
CSNK2B
EGF
EGFR
EPHA2
ERBB2
FBXO25
FPR1
FSHR
GIT1
GIT2
GNA15
GNAQ
GNB2
GNB3
GRM1
HDAC6
KCNIP3
MAPK3
MC4R
MDM2
NCS1
OPRD1
PDC
PDCL
PDE6G
PEBP1
PIK3CG
PLCB1
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
RASGRF1
RCVRN
RHO
RPLP2
SNCA
SRC
TPM2
7 interacting genes:
GRK2
LINC00839
MAPK8
PTEN
RPLP1
SRPK2
YWHAQ
Entrez ID
156
6181
HPRD ID
00182
01612
Ensembl ID
ENSG00000173020
ENSG00000177600
Uniprot IDs
A0A0S2Z392
P25098
A0A024RCA7
P05387
PDB IDs
1BAK
3CIK
3KRW
3KRX
3V5W
4MK0
4PNK
5HE1
5UKK
5UKL
5UUU
5UVC
5WG3
5WG4
5WG5
6C2Y
6U7C
7K7L
7K7Z
1S4J
2JDL
2LBF
2W1O
4BEH
4V6X
5DDZ
5GU4
Enriched GO Terms of Interacting Partners
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