GRK2 and PDE6G

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		GRK2	PDE6G
Description		G protein-coupled receptor kinase 2	phosphodiesterase 6G
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Synapse	Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane
	Molecular Function	Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity	Enzyme Inhibitor Activity Protein Binding Spectrin Binding CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Viral Entry Into Host Cell Cardiac Muscle Contraction Negative Regulation Of Relaxation Of Smooth Muscle	Activation Of MAPK Activity Wnt Signaling Pathway, Calcium Modulating Pathway Visual Perception Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Pathways		Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis	Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Ca2+ pathway Ca2+ pathway
Drugs		ATP	Sildenafil Vardenafil 3-isobutyl-1-methyl-7H-xanthine
Diseases			Retinitis pigmentosa (RP)
GWAS			Blond vs. brown/black hair color ( 30531825) High myopia ( 31816047) Refractive error ( 32231278)
Interacting Genes		51 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 ARRB2 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 ERBB2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB2 GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2	11 interacting genes: BHLHE40 DNM2 FNBP1 GNAO1 GRB2 GRK2 L3MBTL3 MAPK3 PRKAB2 SRC TRIP10
Entrez ID		156	5148
HPRD ID		00182	08914
Ensembl ID		ENSG00000173020	ENSG00000185527
Uniprot IDs		A0A0S2Z392 P25098	P18545
PDB IDs		1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y 6U7C 7K7L 7K7Z	3JWR
Enriched GO Terms of Interacting Partners?
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