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GRK2 and PEBP1
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
GRK2
PEBP1
Description
G protein-coupled receptor kinase 2
phosphatidylethanolamine binding protein 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Cilium
Membrane
Synapse
Nucleus
Cytosol
Extracellular Exosome
Molecular Function
Protein Kinase Activity
G Protein-coupled Receptor Kinase Activity
Protein Binding
ATP Binding
Alpha-2A Adrenergic Receptor Binding
Edg-2 Lysophosphatidic Acid Receptor Binding
Beta-adrenergic Receptor Kinase Activity
RNA Binding
Serine-type Endopeptidase Inhibitor Activity
Protein Binding
ATP Binding
Phosphatidylethanolamine Binding
Enzyme Binding
Protein Kinase Binding
Biological Process
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of The Force Of Heart Contraction By Chemical Signal
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Tachykinin Receptor Signaling Pathway
Heart Development
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Viral Genome Replication
Receptor Internalization
Positive Regulation Of Catecholamine Secretion
Negative Regulation Of Striated Muscle Contraction
Viral Entry Into Host Cell
Cardiac Muscle Contraction
Negative Regulation Of Relaxation Of Smooth Muscle
MAPK Cascade
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of MAPK Cascade
Pathways
Calmodulin induced events
G alpha (q) signalling events
G alpha (s) signalling events
Activation of SMO
Activation of SMO
Cargo recognition for clathrin-mediated endocytosis
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Drugs
ATP
Copper
Diseases
GWAS
Blood protein levels (
30072576
)
Morphine dose requirement in tonsillectomy and adenoidectomy surgery (
24909733
)
Interacting Genes
51 interacting genes:
ADRA2A
ADRB2
AGTR1
AKAP12
ARRB1
ARRB2
BDKRB2
CAPN2
CAV1
CCR4
CCR5
CSNK2B
EGF
EGFR
EPHA2
ERBB2
FBXO25
FPR1
FSHR
GIT1
GIT2
GNA15
GNAQ
GNB2
GNB3
GRM1
HDAC6
KCNIP3
MAPK3
MC4R
MDM2
NCS1
OPRD1
PDC
PDCL
PDE6G
PEBP1
PIK3CG
PLCB1
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
RASGRF1
RCVRN
RHO
RPLP2
SNCA
SRC
TPM2
23 interacting genes:
BRAF
CACHD1
CHUK
ERBB2
GRK2
GSDMB
IKBKB
MAP2K1
MAP3K14
MAP3K7
MAPK1
MED10
NKX3-1
NR2C2
PICK1
PPARD
PRKCA
PRKCB
PRKCD
PRKCG
PRKCZ
RAF1
STC2
Entrez ID
156
5037
HPRD ID
00182
06850
Ensembl ID
ENSG00000173020
ENSG00000089220
Uniprot IDs
A0A0S2Z392
P25098
D9IAI1
P30086
PDB IDs
1BAK
3CIK
3KRW
3KRX
3V5W
4MK0
4PNK
5HE1
5UKK
5UKL
5UUU
5UVC
5WG3
5WG4
5WG5
6C2Y
6U7C
7K7L
7K7Z
1BD9
1BEH
2L7W
2QYQ
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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