GRK2 and PDCL

Data Source:
HPRD (in vitro)

		GRK2	PDCL
Description		G protein-coupled receptor kinase 2	phosducin like
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Synapse	Cytoplasm Cytosol Cilium
	Molecular Function	Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity	Protein Binding Protein-containing Complex Binding
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Viral Entry Into Host Cell Cardiac Muscle Contraction Negative Regulation Of Relaxation Of Smooth Muscle	Protein Folding Signal Transduction Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Protein Refolding Heterotrimeric G-protein Complex Assembly
Pathways		Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		ATP
Diseases
GWAS			Obesity-related traits ( 23251661)
Interacting Genes		51 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 ARRB2 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 ERBB2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB2 GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2	11 interacting genes: CCT3 CCT5 GNB1 GNGT1 GRK2 IKBKG LRRK2 MFHAS1 MRPL11 PSMC5 TCP1
Entrez ID		156	5082
HPRD ID		00182	05108
Ensembl ID		ENSG00000173020	ENSG00000136940
Uniprot IDs		A0A0S2Z392 P25098	Q13371
PDB IDs		1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y 6U7C 7K7L 7K7Z
Enriched GO Terms of Interacting Partners?
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