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CLTC and OPTN
Data Source:
BioGRID
(two hybrid)
CLTC
OPTN
Description
clathrin heavy chain
optineurin
Image
GO Annotations
Cellular Component
Lysosome
Endosome
Spindle
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Clathrin Coat
Clathrin Coat Of Trans-Golgi Network Vesicle
Clathrin Coat Of Coated Pit
Clathrin-coated Vesicle
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Protein-containing Complex
Endolysosome Membrane
Melanosome
Clathrin-coated Endocytic Vesicle
Extracellular Exosome
Clathrin Complex
Mitotic Spindle
Extracellular Vesicle
Mitotic Spindle Microtubule
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Golgi Apparatus
Trans-Golgi Network
Cytosol
Perinuclear Region Of Cytoplasm
Recycling Endosome Membrane
Molecular Function
RNA Binding
Double-stranded RNA Binding
Structural Molecule Activity
Protein Binding
Protein Kinase Binding
Clathrin Light Chain Binding
Low-density Lipoprotein Particle Receptor Binding
Disordered Domain Specific Binding
Ubiquitin-specific Protease Binding
Protein Binding
Protein C-terminus Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Mitotic Cell Cycle
Osteoblast Differentiation
Intracellular Protein Transport
Receptor-mediated Endocytosis
Autophagy
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Receptor Internalization
Low-density Lipoprotein Particle Receptor Catabolic Process
Transferrin Transport
Low-density Lipoprotein Particle Clearance
Retrograde Transport, Endosome To Golgi
Clathrin Coat Assembly
Cell Division
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Mitotic Spindle Organization
Membrane Organization
Clathrin-dependent Endocytosis
Amyloid-beta Clearance By Transcytosis
Negative Regulation Of Hyaluronan Biosynthetic Process
Negative Regulation Of Protein Localization To Plasma Membrane
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Receptor Recycling
Autophagy
Golgi Organization
Signal Transduction
Cell Death
Positive Regulation Of Autophagy
Viral Process
Protein Localization To Golgi Apparatus
Cellular Response To Unfolded Protein
Golgi To Plasma Membrane Protein Transport
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Defense Response To Gram-negative Bacterium
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Golgi Ribbon Formation
Positive Regulation Of Xenophagy
Pathways
Entry of Influenza Virion into Host Cell via Endocytosis
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Lysosome Vesicle Biogenesis
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
Regulation of PLK1 Activity at G2/M Transition
TBC/RABGAPs
Drugs
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Primary open angle glaucoma
GWAS
Cerebrospinal fluid p-tau levels (
29274321
)
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Paget's disease (
21623375
20436471
)
Interacting Genes
61 interacting genes:
ACO1
AFTPH
AMPH
AP1B1
AP1G1
AP3B1
AP3B2
ARMCX3
ARR3
ARRB1
ARRB2
C10orf88
CLINT1
CLTA
CLTB
DNAJC6
DUX4
EPN1
EPN2
ERG
FYN
GAK
GGA1
GGA2
GGA3
GRIN1
GRIN2D
HGS
HIP1
HIP1R
ITSN1
KIT
LDLRAP1
MAP3K10
NCALD
NDRG1
OCRL
OPTN
PICALM
PPP1CA
PPP1CC
PRKACA
PXN
QARS1
SCYL2
SMAP1
SNX5
SNX9
SRC
STAMBP
SUMO2
SYNJ1
TFAP2A
TNK2
TOM1
VCL
WNK1
XRCC6
YWHAG
YWHAQ
ZFYVE9
69 interacting genes:
AIMP1
ARRDC3
ATG16L1
ATG5
CALM1
CCDC13
CDC23
CLTC
CMYA5
DAZAP2
DYSF
DZIP1
FAM189A2
FLII
FOS
FTH1
GABARAP
GABARAPL1
GABARAPL2
GNAS
GRM1
GTF3A
HACE1
HSF2BP
HSPB1
HTT
IRAK1
KANSL1L
LITAF
LNX2
MAP1LC3A
MAP1LC3C
MPP1
MYH3
MYO6
PIAS4
PICK1
POU6F2
RAB11A
RAB11B
RAB12
RAB14
RAB25
RAB8A
RBM12
RFFL
RNF11
RNF216
SDCBP
SLF2
SNX6
TBC1D15
TBC1D17
TNIP1
UBB
UBC
UQCRQ
USP2
VCP
WASHC3
WIPI2
ZNF17
ZNF181
ZNF302
ZNF329
ZNF398
ZNF426
ZNF670
ZNF711
Entrez ID
1213
10133
HPRD ID
00350
03891
Ensembl ID
ENSG00000141367
ENSG00000123240
Uniprot IDs
A0A087WVQ6
Q00610
Q96CV9
PDB IDs
2XZG
4G55
6E4L
6QNN
6QNP
2LO4
2LUE
3VTV
3VTW
5AAZ
5B83
5EOA
5EOF
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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