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OPTN and MYO6
Data Source:
BioGRID
(pull down)
OPTN
MYO6
Description
optineurin
myosin VI
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Golgi Apparatus
Trans-Golgi Network
Cytosol
Perinuclear Region Of Cytoplasm
Recycling Endosome Membrane
Ruffle
Nucleus
Nucleoplasm
Cytoplasm
Lysosomal Membrane
Golgi Apparatus
Cytosol
Actin Filament
Plasma Membrane
Microvillus
Clathrin-coated Pit
Cell Cortex
Actin Cytoskeleton
Membrane
Unconventional Myosin Complex
RNA Polymerase II, Holoenzyme
Endocytic Vesicle
Filopodium
Clathrin-coated Vesicle Membrane
Cytoplasmic Vesicle
Filamentous Actin
Nuclear Membrane
Vesicle
Ruffle Membrane
Clathrin-coated Endocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Protein Binding
Protein C-terminus Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Microfilament Motor Activity
Motor Activity
Actin Binding
Protein Binding
Calmodulin Binding
ATP Binding
Actin-dependent ATPase Activity
ADP Binding
Actin Filament Binding
Minus-end Directed Microfilament Motor Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Receptor Recycling
Autophagy
Golgi Organization
Signal Transduction
Cell Death
Positive Regulation Of Autophagy
Viral Process
Protein Localization To Golgi Apparatus
Cellular Response To Unfolded Protein
Golgi To Plasma Membrane Protein Transport
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Defense Response To Gram-negative Bacterium
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Golgi Ribbon Formation
Positive Regulation Of Xenophagy
Intracellular Protein Transport
Endocytosis
Actin Filament Organization
Sensory Perception Of Sound
Actin Filament-based Movement
Vesicle Transport Along Actin Filament
DNA Damage Response, Signal Transduction By P53 Class Mediator
Inner Ear Morphogenesis
Inner Ear Auditory Receptor Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Secretion
Pathways
Regulation of PLK1 Activity at G2/M Transition
TBC/RABGAPs
Gap junction degradation
Trafficking of AMPA receptors
Drugs
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Primary open angle glaucoma
Deafness, autosomal dominant
Deafness, autosomal recessive
GWAS
Cerebrospinal fluid p-tau levels (
29274321
)
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Paget's disease (
21623375
20436471
)
Prostate cancer (
25217961
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Interacting Genes
69 interacting genes:
AIMP1
ARRDC3
ATG16L1
ATG5
CALM1
CCDC13
CDC23
CLTC
CMYA5
DAZAP2
DYSF
DZIP1
FAM189A2
FLII
FOS
FTH1
GABARAP
GABARAPL1
GABARAPL2
GNAS
GRM1
GTF3A
HACE1
HSF2BP
HSPB1
HTT
IRAK1
KANSL1L
LITAF
LNX2
MAP1LC3A
MAP1LC3C
MPP1
MYH3
MYO6
PIAS4
PICK1
POU6F2
RAB11A
RAB11B
RAB12
RAB14
RAB25
RAB8A
RBM12
RFFL
RNF11
RNF216
SDCBP
SLF2
SNX6
TBC1D15
TBC1D17
TNIP1
UBB
UBC
UQCRQ
USP2
VCP
WASHC3
WIPI2
ZNF17
ZNF181
ZNF302
ZNF329
ZNF398
ZNF426
ZNF670
ZNF711
20 interacting genes:
ACTA1
APC
CALCOCO2
CALM2
CDC42
CDH1
CLTB
DAB1
DAB2
DLG1
GIPC1
LRCH3
OPTN
PAK1
PAK3
RNF11
TOM1
TOM1L2
UBC
WBP2
Entrez ID
10133
4646
HPRD ID
03891
02985
Ensembl ID
ENSG00000123240
ENSG00000196586
Uniprot IDs
Q96CV9
Q9UM54
PDB IDs
2LO4
2LUE
3VTV
3VTW
5AAZ
5B83
5EOA
5EOF
2N0Z
2N10
2N11
2N12
2N13
6E5N
6J56
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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