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CLTC and WNK1
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
CLTC
WNK1
Description
clathrin heavy chain
WNK lysine deficient protein kinase 1
Image
GO Annotations
Cellular Component
Lysosome
Endosome
Spindle
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Clathrin Coat
Clathrin Coat Of Trans-Golgi Network Vesicle
Clathrin Coat Of Coated Pit
Clathrin-coated Vesicle
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Protein-containing Complex
Endolysosome Membrane
Melanosome
Clathrin-coated Endocytic Vesicle
Extracellular Exosome
Clathrin Complex
Mitotic Spindle
Extracellular Vesicle
Mitotic Spindle Microtubule
Cytoplasm
Cytosol
Membrane
Molecular Function
RNA Binding
Double-stranded RNA Binding
Structural Molecule Activity
Protein Binding
Protein Kinase Binding
Clathrin Light Chain Binding
Low-density Lipoprotein Particle Receptor Binding
Disordered Domain Specific Binding
Ubiquitin-specific Protease Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase Inhibitor Activity
Protein Binding
ATP Binding
Chloride Channel Inhibitor Activity
Potassium Channel Inhibitor Activity
Protein Kinase Binding
Phosphatase Binding
Protein Kinase Activator Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Mitotic Cell Cycle
Osteoblast Differentiation
Intracellular Protein Transport
Receptor-mediated Endocytosis
Autophagy
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Receptor Internalization
Low-density Lipoprotein Particle Receptor Catabolic Process
Transferrin Transport
Low-density Lipoprotein Particle Clearance
Retrograde Transport, Endosome To Golgi
Clathrin Coat Assembly
Cell Division
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Mitotic Spindle Organization
Membrane Organization
Clathrin-dependent Endocytosis
Amyloid-beta Clearance By Transcytosis
Negative Regulation Of Hyaluronan Biosynthetic Process
Negative Regulation Of Protein Localization To Plasma Membrane
Regulation Of Sodium Ion Transport
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Ion Transport
Signal Transduction
Negative Regulation Of Sodium Ion Transport
Positive Regulation Of T Cell Chemotaxis
Negative Regulation Of Phosphatase Activity
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Activation Of Protein Kinase Activity
Negative Regulation Of Cell-cell Adhesion Mediated By Integrin
Negative Regulation Of Heterotypic Cell-cell Adhesion
Negative Regulation Of GTPase Activity
Intracellular Signal Transduction
Chemokine (C-C Motif) Ligand 21 Signaling Pathway
Neuron Development
Regulation Of Cellular Process
Ion Homeostasis
T Cell Receptor Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Lymphocyte Migration Into Lymph Node
Negative Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Potassium Ion Import Across Plasma Membrane
Regulation Of Cation Transmembrane Transport
Cellular Response To Chemokine
Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways
Entry of Influenza Virion into Host Cell via Endocytosis
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Lysosome Vesicle Biogenesis
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
Stimuli-sensing channels
Drugs
Diseases
Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS
Adult body size (
32376654
)
Blood protein levels (
29875488
)
Body mass index (
25673413
29273807
)
Body size at age 10 (
32376654
)
Eosinophil counts (
27863252
)
Eosinophil percentage of white cells (
27863252
)
Lung cancer (
28604730
)
Lung cancer in ever smokers (
28604730
)
Manganese levels (
26025379
)
Monocyte percentage of white cells (
32888494
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Squamous cell lung carcinoma (
28604730
)
Stroke (
19369658
)
Interacting Genes
61 interacting genes:
ACO1
AFTPH
AMPH
AP1B1
AP1G1
AP3B1
AP3B2
ARMCX3
ARR3
ARRB1
ARRB2
C10orf88
CLINT1
CLTA
CLTB
DNAJC6
DUX4
EPN1
EPN2
ERG
FYN
GAK
GGA1
GGA2
GGA3
GRIN1
GRIN2D
HGS
HIP1
HIP1R
ITSN1
KIT
LDLRAP1
MAP3K10
NCALD
NDRG1
OCRL
OPTN
PICALM
PPP1CA
PPP1CC
PRKACA
PXN
QARS1
SCYL2
SMAP1
SNX5
SNX9
SRC
STAMBP
SUMO2
SYNJ1
TFAP2A
TNK2
TOM1
VCL
WNK1
XRCC6
YWHAG
YWHAQ
ZFYVE9
36 interacting genes:
ADRB2
AKT1
ARAF
ATXN1
BAG3
CLTC
COPS5
CSDE1
E2F3
FHL3
FLNC
GLIS2
KLHL2
KLHL3
MAP2K1
MAP3K2
MAP3K3
MT-ATP8
PFKP
PRKAR1A
PRKAR1B
PVR
RANBP9
SLC9A1
SYT2
TNRC6A
TSC22D1
TULP3
UBE2I
UPF2
WNK2
YWHAE
YWHAG
YWHAZ
ZNF106
ZYX
Entrez ID
1213
65125
HPRD ID
00350
05570
Ensembl ID
ENSG00000141367
ENSG00000060237
Uniprot IDs
A0A087WVQ6
Q00610
A5D8Z4
F5GWT4
Q9H4A3
PDB IDs
2XZG
4G55
6E4L
6QNN
6QNP
4PWN
5TF9
5WDY
5WE8
6FBK
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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