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OPTN and ZNF329
Data Source:
BioGRID
(two hybrid)
OPTN
ZNF329
Description
optineurin
zinc finger protein 329
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Golgi Apparatus
Trans-Golgi Network
Cytosol
Perinuclear Region Of Cytoplasm
Recycling Endosome Membrane
Nucleus
Molecular Function
Protein Binding
Protein C-terminus Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Protein Binding
Metal Ion Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Receptor Recycling
Autophagy
Golgi Organization
Signal Transduction
Cell Death
Positive Regulation Of Autophagy
Viral Process
Protein Localization To Golgi Apparatus
Cellular Response To Unfolded Protein
Golgi To Plasma Membrane Protein Transport
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Defense Response To Gram-negative Bacterium
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Golgi Ribbon Formation
Positive Regulation Of Xenophagy
Regulation Of Transcription By RNA Polymerase II
Pathways
Regulation of PLK1 Activity at G2/M Transition
TBC/RABGAPs
Drugs
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Primary open angle glaucoma
GWAS
Cerebrospinal fluid p-tau levels (
29274321
)
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Paget's disease (
21623375
20436471
)
Apolipoprotein B levels (
32203549
)
LDL cholesterol levels (
32203549
)
Low density lipoprotein cholesterol levels (
32154731
)
Interacting Genes
69 interacting genes:
AIMP1
ARRDC3
ATG16L1
ATG5
CALM1
CCDC13
CDC23
CLTC
CMYA5
DAZAP2
DYSF
DZIP1
FAM189A2
FLII
FOS
FTH1
GABARAP
GABARAPL1
GABARAPL2
GNAS
GRM1
GTF3A
HACE1
HSF2BP
HSPB1
HTT
IRAK1
KANSL1L
LITAF
LNX2
MAP1LC3A
MAP1LC3C
MPP1
MYH3
MYO6
PIAS4
PICK1
POU6F2
RAB11A
RAB11B
RAB12
RAB14
RAB25
RAB8A
RBM12
RFFL
RNF11
RNF216
SDCBP
SLF2
SNX6
TBC1D15
TBC1D17
TNIP1
UBB
UBC
UQCRQ
USP2
VCP
WASHC3
WIPI2
ZNF17
ZNF181
ZNF302
ZNF329
ZNF398
ZNF426
ZNF670
ZNF711
25 interacting genes:
CARD10
CCDC130
CCDC136
CEP70
CIB3
EMD
GOLGA6L9
KATNBL1
KRT40
KRTAP10-1
KRTAP10-5
KRTAP10-7
MEOX2
MTUS2
OPTN
PICK1
PRKAR1B
SMAD3
TNK1
TRIM37
TRIM41
TSPYL2
ZBTB8A
ZGPAT
ZNF275
Entrez ID
10133
79673
HPRD ID
03891
07779
Ensembl ID
ENSG00000123240
ENSG00000181894
Uniprot IDs
Q96CV9
A0A024R4Q4
Q86UD4
PDB IDs
2LO4
2LUE
3VTV
3VTW
5AAZ
5B83
5EOA
5EOF
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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