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OPTN and MPP1
Data Source:
BioGRID
(pull down)
OPTN
MPP1
Description
optineurin
membrane palmitoylated protein 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Golgi Apparatus
Trans-Golgi Network
Cytosol
Perinuclear Region Of Cytoplasm
Recycling Endosome Membrane
Plasma Membrane
Membrane
Cortical Cytoskeleton
Stereocilium
Centriolar Satellite
Molecular Function
Protein Binding
Protein C-terminus Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Guanylate Kinase Activity
Protein Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Receptor Recycling
Autophagy
Golgi Organization
Signal Transduction
Cell Death
Positive Regulation Of Autophagy
Viral Process
Protein Localization To Golgi Apparatus
Cellular Response To Unfolded Protein
Golgi To Plasma Membrane Protein Transport
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Defense Response To Gram-negative Bacterium
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Golgi Ribbon Formation
Positive Regulation Of Xenophagy
Signal Transduction
GMP Metabolic Process
GDP Metabolic Process
Regulation Of Neutrophil Chemotaxis
Pathways
Regulation of PLK1 Activity at G2/M Transition
TBC/RABGAPs
Drugs
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Primary open angle glaucoma
GWAS
Cerebrospinal fluid p-tau levels (
29274321
)
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Paget's disease (
21623375
20436471
)
Hematology traits (
23263863
)
Mean corpuscular volume (
23263863
)
Red blood cell traits (
23446634
)
Interacting Genes
69 interacting genes:
AIMP1
ARRDC3
ATG16L1
ATG5
CALM1
CCDC13
CDC23
CLTC
CMYA5
DAZAP2
DYSF
DZIP1
FAM189A2
FLII
FOS
FTH1
GABARAP
GABARAPL1
GABARAPL2
GNAS
GRM1
GTF3A
HACE1
HSF2BP
HSPB1
HTT
IRAK1
KANSL1L
LITAF
LNX2
MAP1LC3A
MAP1LC3C
MPP1
MYH3
MYO6
PIAS4
PICK1
POU6F2
RAB11A
RAB11B
RAB12
RAB14
RAB25
RAB8A
RBM12
RFFL
RNF11
RNF216
SDCBP
SLF2
SNX6
TBC1D15
TBC1D17
TNIP1
UBB
UBC
UQCRQ
USP2
VCP
WASHC3
WIPI2
ZNF17
ZNF181
ZNF302
ZNF329
ZNF398
ZNF426
ZNF670
ZNF711
43 interacting genes:
ABCC4
ACER1
ACER2
AGPAT3
AMOTL2
AP2M1
APH1A
ATP5F1C
ATRAID
BHLHB9
DERL2
DGAT2L6
DNPEP
ERBIN
GADD45A
GSK3B
GYPC
HNRNPD
INCA1
KLHL12
MAP3K20
MEOX2
NR1H2
OPTN
PAQR8
PRIMPOL
RPRM
RPS6KA1
RPS6KA6
SGSM2
SLC35E1
SMN1
SRSF10
STK3
STUB1
SYNGR3
TK1
TMEM239
TRIM55
TRIM63
USP21
UXT
ZNF639
Entrez ID
10133
4354
HPRD ID
03891
02370
Ensembl ID
ENSG00000123240
ENSG00000130830
Uniprot IDs
Q96CV9
B4E325
Q00013
PDB IDs
2LO4
2LUE
3VTV
3VTW
5AAZ
5B83
5EOA
5EOF
2EJY
2EV8
3NEY
Enriched GO Terms of Interacting Partners
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