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OPTN and DAZAP2
Data Source:
BioGRID
(two hybrid)
OPTN
DAZAP2
Description
optineurin
DAZ associated protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Golgi Apparatus
Trans-Golgi Network
Cytosol
Perinuclear Region Of Cytoplasm
Recycling Endosome Membrane
Cytoplasm
Nuclear Speck
Protein-containing Complex
Molecular Function
Protein Binding
Protein C-terminus Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Protein Binding
Receptor Tyrosine Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
WW Domain Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Receptor Recycling
Autophagy
Golgi Organization
Signal Transduction
Cell Death
Positive Regulation Of Autophagy
Viral Process
Protein Localization To Golgi Apparatus
Cellular Response To Unfolded Protein
Golgi To Plasma Membrane Protein Transport
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Defense Response To Gram-negative Bacterium
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Golgi Ribbon Formation
Positive Regulation Of Xenophagy
Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways
Regulation of PLK1 Activity at G2/M Transition
TBC/RABGAPs
Drugs
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Primary open angle glaucoma
GWAS
Cerebrospinal fluid p-tau levels (
29274321
)
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Paget's disease (
21623375
20436471
)
Interacting Genes
69 interacting genes:
AIMP1
ARRDC3
ATG16L1
ATG5
CALM1
CCDC13
CDC23
CLTC
CMYA5
DAZAP2
DYSF
DZIP1
FAM189A2
FLII
FOS
FTH1
GABARAP
GABARAPL1
GABARAPL2
GNAS
GRM1
GTF3A
HACE1
HSF2BP
HSPB1
HTT
IRAK1
KANSL1L
LITAF
LNX2
MAP1LC3A
MAP1LC3C
MPP1
MYH3
MYO6
PIAS4
PICK1
POU6F2
RAB11A
RAB11B
RAB12
RAB14
RAB25
RAB8A
RBM12
RFFL
RNF11
RNF216
SDCBP
SLF2
SNX6
TBC1D15
TBC1D17
TNIP1
UBB
UBC
UQCRQ
USP2
VCP
WASHC3
WIPI2
ZNF17
ZNF181
ZNF302
ZNF329
ZNF398
ZNF426
ZNF670
ZNF711
164 interacting genes:
AATF
ACOT7
AOC1
ARID5A
ATXN1
ATXN1L
BAG3
BATF2
BHLHE40
C1orf94
CALCOCO2
CAMK2A
CAPN15
CCDC120
CDK4
CELF5
CEP70
CLASRP
COL4A2
COL4A5
CXCL12
DAB1
DAZ1
DAZL
DCUN1D1
DESI1
DTX2
EPN1
EPN2
EPN3
ESRP1
EXD3
FAM168A
FAM83A
FBN3
FOXH1
GGA3
GPS2
GPSM1
HEY1
HGS
HIP1
INCA1
KLHL42
KRTAP19-1
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP26-1
KRTAP6-1
KRTAP6-2
KRTAP8-1
LASP1
LGALS9
LITAF
LMO2
MAGED1
MAPK1IP1L
MED31
MINDY1
MINDY3
MTURN
MYEOV
MYOZ3
NDUFA5
NEDD4
NEDD4L
NOC4L
NOTCH1
OPTN
OTUB2
OTUD7B
OTULIN
PATZ1
PDIK1L
PEF1
PITX2
PLEKHB2
PLEKHF2
PLSCR1
PLSCR4
POGZ
POLI
PROP1
PRR13
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PRR34
RABGEF1
RAD18
RAD23A
RAMAC
RBFOX1
RBFOX2
RBM11
RBM24
RBM43
RBPMS
RHOXF2
RNF115
RNF208
RNF44
ROR2
RPS27A
SEPTIN2
SMAP2
SMURF2
SNRPC
SOX10
SOX6
SQSTM1
STAM2
STAT6
TAX1BP1
TBX6
TCF7L2
TENT5B
TENT5C
TEX37
TFG
TIAL1
TLE1
TLE5
TNIP1
TNIP3
TOLLIP
TOM1
UBA52
UBAC1
UBAP2
UBASH3A
UBASH3B
UBB
UBC
UBE2D4
UBE2E2
UBE2E3
UBE2V1
UBE3A
UBQLN1
UBQLN2
UBQLN4
UBXN6
UBXN7
USP13
USP5
VENTX
VEZF1
VHLL
VPS37C
WDR73
WWOX
WWP1
YOD1
ZBTB32
ZC3H10
ZFAND2A
ZFAND2B
ZFYVE9
ZNF34
ZNF581
Entrez ID
10133
9802
HPRD ID
03891
08463
Ensembl ID
ENSG00000123240
ENSG00000183283
Uniprot IDs
Q96CV9
A0A024R110
Q15038
PDB IDs
2LO4
2LUE
3VTV
3VTW
5AAZ
5B83
5EOA
5EOF
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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