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OPTN and RNF11
Data Source:
HPRD
(two hybrid)
OPTN
RNF11
Description
optineurin
ring finger protein 11
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Golgi Apparatus
Trans-Golgi Network
Cytosol
Perinuclear Region Of Cytoplasm
Recycling Endosome Membrane
Ubiquitin Ligase Complex
Nucleus
Early Endosome
Recycling Endosome
Extracellular Exosome
Molecular Function
Protein Binding
Protein C-terminus Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
DNA Binding
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Receptor Recycling
Autophagy
Golgi Organization
Signal Transduction
Cell Death
Positive Regulation Of Autophagy
Viral Process
Protein Localization To Golgi Apparatus
Cellular Response To Unfolded Protein
Golgi To Plasma Membrane Protein Transport
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Defense Response To Gram-negative Bacterium
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Golgi Ribbon Formation
Positive Regulation Of Xenophagy
Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Pathways
Regulation of PLK1 Activity at G2/M Transition
TBC/RABGAPs
Drugs
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Primary open angle glaucoma
GWAS
Cerebrospinal fluid p-tau levels (
29274321
)
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Paget's disease (
21623375
20436471
)
Atrial fibrillation (
29290336
)
Male-pattern baldness (
28196072
)
QRS duration (
21076409
)
Interacting Genes
69 interacting genes:
AIMP1
ARRDC3
ATG16L1
ATG5
CALM1
CCDC13
CDC23
CLTC
CMYA5
DAZAP2
DYSF
DZIP1
FAM189A2
FLII
FOS
FTH1
GABARAP
GABARAPL1
GABARAPL2
GNAS
GRM1
GTF3A
HACE1
HSF2BP
HSPB1
HTT
IRAK1
KANSL1L
LITAF
LNX2
MAP1LC3A
MAP1LC3C
MPP1
MYH3
MYO6
PIAS4
PICK1
POU6F2
RAB11A
RAB11B
RAB12
RAB14
RAB25
RAB8A
RBM12
RFFL
RNF11
RNF216
SDCBP
SLF2
SNX6
TBC1D15
TBC1D17
TNIP1
UBB
UBC
UQCRQ
USP2
VCP
WASHC3
WIPI2
ZNF17
ZNF181
ZNF302
ZNF329
ZNF398
ZNF426
ZNF670
ZNF711
68 interacting genes:
AKT1
ANKRD13A
ANKRD28
APP
ASCC2
AUP1
CALCOCO2
CBLB
CCDC127
DCUN1D1
EPN1
EPN2
EPN3
EPS15
ERCC6
FANCL
GGA1
GGA2
GGA3
HERC1
HERC2
HUWE1
IKBKG
ITCH
MYO6
NEDD4
NEDD4L
OPTN
PDCD6IP
POLI
PTPRC
QARS1
RABGEF1
RIPK1
RNF168
RNF216
RPS27A
SDCBP
SMURF1
SMURF2
SNRNP70
SPRTN
STAM2
STAMBP
TAX1BP1
TNFAIP3
TNIP1
TOM1L2
UBA52
UBAC1
UBB
UBC
UBE2D1
UBE2D2
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2U
UBQLN2
UBQLN4
USP5
WWP1
WWP2
ZFYVE16
ZFYVE9
ZNF350
Entrez ID
10133
26994
HPRD ID
03891
09955
Ensembl ID
ENSG00000123240
ENSG00000123091
Uniprot IDs
Q96CV9
Q9Y3C5
PDB IDs
2LO4
2LUE
3VTV
3VTW
5AAZ
5B83
5EOA
5EOF
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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