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CLTC and OCRL
Data Source:
HPRD
(in vitro, two hybrid)
CLTC
OCRL
Description
clathrin heavy chain
OCRL inositol polyphosphate-5-phosphatase
Image
GO Annotations
Cellular Component
Lysosome
Endosome
Spindle
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Clathrin Coat
Clathrin Coat Of Trans-Golgi Network Vesicle
Clathrin Coat Of Coated Pit
Clathrin-coated Vesicle
Clathrin-coated Endocytic Vesicle Membrane
Trans-Golgi Network Membrane
Protein-containing Complex
Endolysosome Membrane
Melanosome
Clathrin-coated Endocytic Vesicle
Extracellular Exosome
Clathrin Complex
Mitotic Spindle
Extracellular Vesicle
Mitotic Spindle Microtubule
Photoreceptor Outer Segment
Nucleus
Cytoplasm
Lysosome
Early Endosome
Golgi Stack
Golgi-associated Vesicle
Trans-Golgi Network
Cytosol
Plasma Membrane
Clathrin-coated Pit
Membrane
Clathrin-coated Vesicle
Phagocytic Vesicle Membrane
Early Endosome Membrane
Molecular Function
RNA Binding
Double-stranded RNA Binding
Structural Molecule Activity
Protein Binding
Protein Kinase Binding
Clathrin Light Chain Binding
Low-density Lipoprotein Particle Receptor Binding
Disordered Domain Specific Binding
Ubiquitin-specific Protease Binding
Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity
Inositol-polyphosphate 5-phosphatase Activity
GTPase Activator Activity
Protein Binding
Small GTPase Binding
Inositol-1,4,5-trisphosphate 5-phosphatase Activity
Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
Inositol Phosphate Phosphatase Activity
Biological Process
Mitotic Cell Cycle
Osteoblast Differentiation
Intracellular Protein Transport
Receptor-mediated Endocytosis
Autophagy
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Receptor Internalization
Low-density Lipoprotein Particle Receptor Catabolic Process
Transferrin Transport
Low-density Lipoprotein Particle Clearance
Retrograde Transport, Endosome To Golgi
Clathrin Coat Assembly
Cell Division
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Mitotic Spindle Organization
Membrane Organization
Clathrin-dependent Endocytosis
Amyloid-beta Clearance By Transcytosis
Negative Regulation Of Hyaluronan Biosynthetic Process
Negative Regulation Of Protein Localization To Plasma Membrane
Lipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
Signal Transduction
Regulation Of GTPase Activity
Positive Regulation Of GTPase Activity
Inositol Phosphate Metabolic Process
Inositol Phosphate Dephosphorylation
Phosphatidylinositol Dephosphorylation
Regulation Of Small GTPase Mediated Signal Transduction
Cilium Assembly
Membrane Organization
Pathways
Entry of Influenza Virion into Host Cell via Endocytosis
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Lysosome Vesicle Biogenesis
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the Golgi membrane
Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of IP3 and IP4 in the cytosol
Rho GTPase cycle
Golgi Associated Vesicle Biogenesis
Clathrin-mediated endocytosis
Drugs
Diseases
Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis
Lowe syndrome; Oculocerebrorenal Dystrophy (OCRL)
GWAS
Interacting Genes
61 interacting genes:
ACO1
AFTPH
AMPH
AP1B1
AP1G1
AP3B1
AP3B2
ARMCX3
ARR3
ARRB1
ARRB2
C10orf88
CLINT1
CLTA
CLTB
DNAJC6
DUX4
EPN1
EPN2
ERG
FYN
GAK
GGA1
GGA2
GGA3
GRIN1
GRIN2D
HGS
HIP1
HIP1R
ITSN1
KIT
LDLRAP1
MAP3K10
NCALD
NDRG1
OCRL
OPTN
PICALM
PPP1CA
PPP1CC
PRKACA
PXN
QARS1
SCYL2
SMAP1
SNX5
SNX9
SRC
STAMBP
SUMO2
SYNJ1
TFAP2A
TNK2
TOM1
VCL
WNK1
XRCC6
YWHAG
YWHAQ
ZFYVE9
14 interacting genes:
CDC42
CLTC
GOLGA5
GRB2
LHX3
PHETA1
PHETA2
RAB14
RAB1A
RAB31
RAB5A
RAB6A
RAB8A
RAC1
Entrez ID
1213
4952
HPRD ID
00350
02395
Ensembl ID
ENSG00000141367
ENSG00000122126
Uniprot IDs
A0A087WVQ6
Q00610
A0A2X0TVZ9
Q01968
Q504W7
PDB IDs
2XZG
4G55
6E4L
6QNN
6QNP
2KIE
2QV2
3QBT
3QIS
4CMN
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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