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KLHL2 and UBE2C
Data Source:
BioGRID
(two hybrid)
KLHL2
UBE2C
Description
kelch like family member 2
ubiquitin conjugating enzyme E2 C
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Cytosol
Actin Cytoskeleton
Lamellipodium
Cul3-RING Ubiquitin Ligase Complex
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Plasma Membrane
Molecular Function
Actin Binding
Protein Binding
Identical Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin-like Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Ubiquitination
Post-translational Protein Modification
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Exit From Mitosis
Cell Division
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Cognitive function (
24684796
)
General cognitive ability (
29844566
)
Neuroticism (
27067015
)
Height (
31562340
)
Interacting Genes
31 interacting genes:
ACTC1
BCAM
BYSL
C20orf85
CCDC43
CDC37
CLK2
CUL3
CWC22
ELOA
KEAP1
KLHL12
KLHL3
MFAP1
NAP1L2
NTAQ1
PADI6
PIBF1
POLR3C
SDCBP
TMA16
TNPO2
TRIM50
TXNDC12
UBE2C
UBE2D1
UBE2I
UCK1
WNK1
WNK4
ZNF114
33 interacting genes:
ANAPC11
ANAPC2
AURKA
CCNA2
CCNB1
CDC20
CKAP2
CXCR1
DTX1
ENO2
FBXO5
FZR1
GMNN
ITCH
KLHL2
MAPK7
PCGF3
POLM
PRKN
PSMD4
PTTG1
RAG1
RELA
RNF31
RNF7
TNNC1
TRIM21
TRIM28
TRIM29
TRIM72
UBA1
UBASH3B
UBE3D
Entrez ID
11275
11065
HPRD ID
09311
05717
Ensembl ID
ENSG00000109466
ENSG00000175063
Uniprot IDs
B4DFZ5
E9PEX9
O95198
A0A087WVK1
A0A0A0MSE8
O00762
Q5TZN3
PDB IDs
2XN4
4CHB
1I7K
4YII
5A31
5KHR
5L9U
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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