UBE2C and TRIM72

Data Source:
BioGRID (enzymatic study)

		UBE2C	TRIM72
Description		ubiquitin conjugating enzyme E2 C	tripartite motif containing 72
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Plasma Membrane	Cytoplasm Cytoplasmic Vesicle Membrane Sarcolemma
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin-like Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Phosphatidylserine Binding Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Exit From Mitosis Cell Division Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity	Plasma Membrane Repair Muscle System Process Exocytosis Muscle Contraction Muscle Organ Development Negative Regulation Of Myotube Differentiation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Protein Homooligomerization
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Smooth Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS		Height ( 31562340)
Interacting Genes		33 interacting genes: ANAPC11 ANAPC2 AURKA CCNA2 CCNB1 CDC20 CKAP2 CXCR1 DTX1 ENO2 FBXO5 FZR1 GMNN ITCH KLHL2 MAPK7 PCGF3 POLM PRKN PSMD4 PTTG1 RAG1 RELA RNF31 RNF7 TNNC1 TRIM21 TRIM28 TRIM29 TRIM72 UBA1 UBASH3B UBE3D	18 interacting genes: ABI2 C1orf216 INSR IRS1 MED21 MZT1 NMI PPP3CA SMARCD1 TCF12 TRIM32 UBE2C UBE2D3 UBE2H UBE2I UBE2N VSIG4 ZNF655
Entrez ID		11065	493829
HPRD ID		05717	17412
Ensembl ID		ENSG00000175063	ENSG00000177238
Uniprot IDs		A0A087WVK1 A0A0A0MSE8 O00762 Q5TZN3	Q6ZMU5
PDB IDs		1I7K 4YII 5A31 5KHR 5L9U	3KB5
Enriched GO Terms of Interacting Partners?
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