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UBE2C and TRIM29
Data Source:
BioGRID
(pull down)
UBE2C
TRIM29
Description
ubiquitin conjugating enzyme E2 C
tripartite motif containing 29
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Plasma Membrane
Lysosome
Adherens Junction
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin-like Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
P53 Binding
Protein Binding
Zinc Ion Binding
Identical Protein Binding
Cadherin Binding Involved In Cell-cell Adhesion
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Exit From Mitosis
Cell Division
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Innate Immune Response
Cell-cell Adhesion
Negative Regulation Of Protein Localization To Nucleus
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Interferon gamma signaling
Drugs
Diseases
GWAS
Height (
31562340
)
Corneal curvature (
22969067
)
Disease progression in age-related macular degeneration (adjusted for baseline) (
29346644
)
Resistance to antihypertensive treatment in hypertension (
31545351
)
Retinal detachment or retinal break (
31816047
)
Stroke (pediatric) (
22990015
)
Interacting Genes
33 interacting genes:
ANAPC11
ANAPC2
AURKA
CCNA2
CCNB1
CDC20
CKAP2
CXCR1
DTX1
ENO2
FBXO5
FZR1
GMNN
ITCH
KLHL2
MAPK7
PCGF3
POLM
PRKN
PSMD4
PTTG1
RAG1
RELA
RNF31
RNF7
TNNC1
TRIM21
TRIM28
TRIM29
TRIM72
UBA1
UBASH3B
UBE3D
54 interacting genes:
ACTN3
ANKS1A
ATM
CARD9
CCDC57
CDC34
CEP70
CRACR2A
DISC1
DMRT1
FBF1
FBXL19
FXR2
GATA1
GCC1
GOLGA2
GTF2E1
H4C1
HCLS1
HDAC9
HINT1
IKBKG
JAKMIP2
KAT5
KRT35
LZTS2
MAD1L1
MAPKAPK2
MED7
MID2
MLH1
MSH2
MTUS2
MYO15B
NFKBID
POLR2D
POLR2E
PRICKLE3
PRKCA
RNF8
SHOX2
SMAD9
SNAPC1
SP100
TAX1BP3
TRIM11
TRIM23
TRIM27
TRIP6
TSGA10
UBE2C
UBE2E1
UBE2I
VIM
Entrez ID
11065
23650
HPRD ID
05717
10280
Ensembl ID
ENSG00000175063
ENSG00000137699
Uniprot IDs
A0A087WVK1
A0A0A0MSE8
O00762
Q5TZN3
A0A024R3J1
B7Z5V5
B7Z8U9
E9PRL4
Q14134
PDB IDs
1I7K
4YII
5A31
5KHR
5L9U
2CSV
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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