KLHL2 and CWC22

Data Source:
BioGRID (two hybrid)

		KLHL2	CWC22
Description		kelch like family member 2	CWC22 spliceosome associated protein homolog
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Speck U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	RNA Binding Protein Binding
	Biological Process	Protein Ubiquitination Post-translational Protein Modification	MRNA Splicing, Via Spliceosome Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Adult body size ( 32376654) Body mass index ( 28892062) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Schizophrenia ( 30285260)
Interacting Genes		31 interacting genes: ACTC1 BCAM BYSL C20orf85 CCDC43 CDC37 CLK2 CUL3 CWC22 ELOA KEAP1 KLHL12 KLHL3 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	4 interacting genes: EIF4A3 EXOSC8 KLHL2 PTPN21
Entrez ID		11275	57703
HPRD ID		09311	17220
Ensembl ID		ENSG00000109466	ENSG00000163510
Uniprot IDs		B4DFZ5 E9PEX9 O95198	Q9HCG8
PDB IDs		2XN4 4CHB	4C9B 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF7 6ICZ 6QDV 6YVH 6ZYM 7A5P
Enriched GO Terms of Interacting Partners?
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