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UBE2C and CXCR1
Data Source:
BioGRID
(two hybrid)
UBE2C
CXCR1
Description
ubiquitin conjugating enzyme E2 C
C-X-C motif chemokine receptor 1
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Plasma Membrane
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Secretory Granule Membrane
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin-like Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
Interleukin-8 Receptor Activity
G Protein-coupled Receptor Activity
Chemokine Receptor Activity
Protein Binding
C-C Chemokine Receptor Activity
C-C Chemokine Binding
Interleukin-8 Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Exit From Mitosis
Cell Division
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Dendritic Cell Chemotaxis
Immune Response
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Calcium-mediated Signaling
Neutrophil Chemotaxis
Receptor Internalization
Interleukin-8-mediated Signaling Pathway
Neutrophil Degranulation
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation
Drugs
Ketoprofen
Diseases
GWAS
Height (
31562340
)
Basophil count (
32888494
)
Diffusing capacity of carbon monoxide (
30694715
)
Idiopathic intracranial hypertension (
29608535
)
Inflammatory bowel disease (
28067908
23128233
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil count (
29403010
)
Smooth-surface caries (
23470693
)
White blood cell count (
29403010
)
Interacting Genes
33 interacting genes:
ANAPC11
ANAPC2
AURKA
CCNA2
CCNB1
CDC20
CKAP2
CXCR1
DTX1
ENO2
FBXO5
FZR1
GMNN
ITCH
KLHL2
MAPK7
PCGF3
POLM
PRKN
PSMD4
PTTG1
RAG1
RELA
RNF31
RNF7
TNNC1
TRIM21
TRIM28
TRIM29
TRIM72
UBA1
UBASH3B
UBE3D
20 interacting genes:
ADRA1A
CDK1
CLDND1
CXCL1
CXCL2
CXCL3
CXCL5
CXCL6
CXCL8
CXCR2
FATE1
GNA14
GNA15
GNAI2
IGFBP5
PDCD6IP
PPBP
TRARG1
TUBA1A
UBE2C
Entrez ID
11065
3577
HPRD ID
05717
00908
Ensembl ID
ENSG00000175063
ENSG00000163464
Uniprot IDs
A0A087WVK1
A0A0A0MSE8
O00762
Q5TZN3
P25024
PDB IDs
1I7K
4YII
5A31
5KHR
5L9U
1ILP
1ILQ
2LNL
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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