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UBE2C and RNF7
Data Source:
BioGRID
(affinity chromatography technology, pull down, pull down)
UBE2C
RNF7
Description
ubiquitin conjugating enzyme E2 C
ring finger protein 7
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Plasma Membrane
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cullin-RING Ubiquitin Ligase Complex
Cul5-RING Ubiquitin Ligase Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin-like Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
Copper Ion Binding
Protein Binding
Zinc Ion Binding
NEDD8 Transferase Activity
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Cullin Family Protein Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Exit From Mitosis
Cell Division
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Protein Phosphopantetheinylation
Post-translational Protein Modification
Protein Neddylation
Response To Redox State
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Height (
31562340
)
Hepatitis C induced liver fibrosis (
22841784
)
Pelvic organ prolapse (moderate/severe) (
26545240
)
Interacting Genes
33 interacting genes:
ANAPC11
ANAPC2
AURKA
CCNA2
CCNB1
CDC20
CKAP2
CXCR1
DTX1
ENO2
FBXO5
FZR1
GMNN
ITCH
KLHL2
MAPK7
PCGF3
POLM
PRKN
PSMD4
PTTG1
RAG1
RELA
RNF31
RNF7
TNNC1
TRIM21
TRIM28
TRIM29
TRIM72
UBA1
UBASH3B
UBE3D
43 interacting genes:
APOBEC3F
APOBEC3G
ASB11
BTRC
CASP7
CBFB
CDC34
CHFR
CSNK2A1
CSNK2B
CUL1
CUL2
CUL3
CUL4A
CUL4B
CUL5
CYCS
ELOB
ELOC
ERBIN
GEM
GHR
GLMN
IKBKG
ITM2C
MKRN3
MNAT1
NEDD4
NEDD4L
PLA2G15
PMAIP1
SOCS3
TRIM46
TRIM8
UBE2C
UBE2D1
UBE2D2
UBE2D4
UBE2F
UBE2L3
UBE2M
UBE2Q1
UBE2S
Entrez ID
11065
9616
HPRD ID
05717
04840
Ensembl ID
ENSG00000175063
ENSG00000114125
Uniprot IDs
A0A087WVK1
A0A0A0MSE8
O00762
Q5TZN3
Q9UBF6
PDB IDs
1I7K
4YII
5A31
5KHR
5L9U
2ECL
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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