KLHL2 and MFAP1

Data Source:
BioGRID (two hybrid)

		KLHL2	MFAP1
Description		kelch like family member 2	microfibril associated protein 1
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex	Microfibril Extracellular Region Nucleus Nucleoplasm U2-type Spliceosomal Complex Centrosome U2-type Precatalytic Spliceosome
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding	RNA Binding Protein Binding
	Biological Process	Protein Ubiquitination Post-translational Protein Modification	MRNA Splicing, Via Spliceosome
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)	Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643)
Interacting Genes		31 interacting genes: ACTC1 BCAM BYSL C20orf85 CCDC43 CDC37 CLK2 CUL3 CWC22 ELOA KEAP1 KLHL12 KLHL3 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	90 interacting genes: ALKBH8 AMOTL2 AP2M1 BEND7 BHLHB9 BICD2 CARD9 CCDC102B CCDC33 CCDC57 CDC14B CDCA7L CEP55 CEP57L1 CEP70 CEP76 COG6 COIL CSNK2A1 DHX38 DHX8 DNTTIP1 FAM9B FRA10AC1 FXR1 FXR2 GAS8 GKAP1 GOLGA2 GOLGA6L9 GRIPAP1 HMBOX1 HOMER3 HOOK2 HSF2BP HSPB1 IK KATNBL1 KIFC3 KLHL2 KRT40 L3MBTL3 LDOC1 LMNA LMNB2 LZTS1 MAD1L1 MCRS1 MID2 MIPOL1 MTUS2 NDC80 NGDN OLIG3 PAX6 PHC2 PIBF1 PIH1D1 PLEKHF2 SART1 SNW1 SSX2IP STAC3 STX11 TADA2A TCP10L TEPSIN TFIP11 THAP1 TLE5 TRAF2 TRIM41 TRIM42 TRIM54 U2AF1 VPS52 YWHAG ZBTB1 ZBTB14 ZBTB8A ZFP1 ZFP41 ZFP64 ZNF398 ZNF41 ZNF558 ZNF620 ZNF71 ZNF76 ZRANB1
Entrez ID		11275	4236
HPRD ID		09311	02569
Ensembl ID		ENSG00000109466	ENSG00000140259
Uniprot IDs		B4DFZ5 E9PEX9 O95198	P55081
PDB IDs		2XN4 4CHB	5F5S 5O9Z 6AHD
Enriched GO Terms of Interacting Partners?
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