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UBE2C and PTTG1
Data Source:
BioGRID
(enzymatic study)
UBE2C
PTTG1
Description
ubiquitin conjugating enzyme E2 C
PTTG1 regulator of sister chromatid separation, securin
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Plasma Membrane
Nucleus
Cytoplasm
Cytosol
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin-like Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
Cysteine-type Endopeptidase Inhibitor Activity
Protein Binding
SH3 Domain Binding
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Exit From Mitosis
Cell Division
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Spermatogenesis
Negative Regulation Of Endopeptidase Activity
Anaphase-promoting Complex-dependent Catabolic Process
Homologous Chromosome Segregation
Chromosome Organization
Cell Division
Negative Regulation Of Mitotic Sister Chromatid Separation
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Drugs
Diseases
GWAS
Height (
31562340
)
Dermatomyositis or juvenile dermatomyositis (
26362759
)
Insulin-related traits (
22791750
)
Sjögren's syndrome (
24097067
)
Systemic lupus erythematosus (
21408207
28714469
19838195
)
Systemic lupus erythematosus or rheumatoid arthritis (
27193031
)
Interacting Genes
33 interacting genes:
ANAPC11
ANAPC2
AURKA
CCNA2
CCNB1
CDC20
CKAP2
CXCR1
DTX1
ENO2
FBXO5
FZR1
GMNN
ITCH
KLHL2
MAPK7
PCGF3
POLM
PRKN
PSMD4
PTTG1
RAG1
RELA
RNF31
RNF7
TNNC1
TRIM21
TRIM28
TRIM29
TRIM72
UBA1
UBASH3B
UBE3D
23 interacting genes:
ANAPC11
ANAPC2
AURKA
CAMK2A
CDC20
CDC27
CDC34
CDK1
CRK
CUL1
DNAJA1
FZR1
PLCG2
PPP2R2D
PPP2R5A
PRKN
PTTG1IP
RPS10
TP53
UBE2C
UBE2N
UBE4A
XRCC6
Entrez ID
11065
9232
HPRD ID
05717
04998
Ensembl ID
ENSG00000175063
ENSG00000164611
Uniprot IDs
A0A087WVK1
A0A0A0MSE8
O00762
Q5TZN3
O95997
Q6IAL9
PDB IDs
1I7K
4YII
5A31
5KHR
5L9U
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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