IRAK3 and ATP6V0B

Data Source:
BioGRID (two hybrid)

		IRAK3	ATP6V0B
Description		interleukin 1 receptor associated kinase 3	ATPase H+ transporting V0 subunit b
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Vacuolar Membrane Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Transporter Activity Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Phagosome Acidification Proton Transmembrane Transport
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Fostamatinib	Tiludronic acid
Diseases
GWAS		Smooth-surface caries ( 24556642) White blood cell count (basophil) ( 29403010)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6	28 interacting genes: ADGRG3 ADRB2 APOD COL4A5 EMP1 FAM210B FAS GJA8 GPR42 GPR61 INSIG2 IRAK3 KLRC1 MFF MIP MS4A3 MTNR1B NRM SLC10A1 SLC2A5 SNTA1 SPACA1 STOM TM4SF19 TMEM242 VMA21 YWHAE YWHAG
Entrez ID		11213	533
HPRD ID		05123	04759
Ensembl ID		ENSG00000090376	ENSG00000117410
Uniprot IDs		Q9Y616	E9PNL3 Q99437
PDB IDs		5UKE 6RUU 6ZIW
Enriched GO Terms of Interacting Partners?
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