IRAK3 and FOLR1

Data Source:
BioGRID (two hybrid)

		IRAK3	FOLR1
Description		interleukin 1 receptor associated kinase 3	folate receptor alpha
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Golgi Membrane Nucleus Endosome Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Clathrin-coated Vesicle Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Folic Acid Binding Signaling Receptor Activity Methotrexate Binding Folic Acid Receptor Activity
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Heart Looping Neural Crest Cell Migration Involved In Heart Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Cell Adhesion Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Folic Acid Transport Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Sperm-egg Recognition Folic Acid Metabolic Process COPII Vesicle Coating Regulation Of Canonical Wnt Signaling Pathway Pharyngeal Arch Artery Morphogenesis Anterior Neural Tube Closure Cellular Response To Folic Acid Folate Import Across Plasma Membrane
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport
Drugs		Fostamatinib	Folic acid Vintafolide Farletuzumab
Diseases
GWAS		Smooth-surface caries ( 24556642) White blood cell count (basophil) ( 29403010)
Interacting Genes		17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6	6 interacting genes: CUL3 IRAK3 LTB4R2 LYN NCAPH2 SLC35F6
Entrez ID		11213	2348
HPRD ID		05123	00638
Ensembl ID		ENSG00000090376	ENSG00000110195
Uniprot IDs		Q9Y616	A0A024R5H1 P15328
PDB IDs		5UKE 6RUU 6ZIW	4KM6 4KM7 4KMX 4LRH 5IZQ
Enriched GO Terms of Interacting Partners?
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