IRAK3 and NSA2

Data Source:
BioGRID (two hybrid)

		IRAK3	NSA2
Description		interleukin 1 receptor associated kinase 3	NSA2 ribosome biogenesis factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nucleolus Preribosome, Large Subunit Precursor
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Maturation Of 5.8S RRNA Maturation Of LSU-rRNA
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling
Drugs		Fostamatinib
Diseases
GWAS		Smooth-surface caries ( 24556642) White blood cell count (basophil) ( 29403010)
Interacting Genes		17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6	1 interacting genes: IRAK3
Entrez ID		11213	10412
HPRD ID		05123	18191
Ensembl ID		ENSG00000090376	ENSG00000164346
Uniprot IDs		Q9Y616	A0A0A0MQZ6 O95478 Q5J7U2
PDB IDs		5UKE 6RUU 6ZIW
Enriched GO Terms of Interacting Partners?
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