IRAK3 and ADH1B

Data Source:
BioGRID (two hybrid)

		IRAK3	ADH1B
Description		interleukin 1 receptor associated kinase 3	alcohol dehydrogenase 1B (class I), beta polypeptide
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Alcohol Dehydrogenase Activity, Zinc-dependent Retinol Dehydrogenase Activity Zinc Ion Binding
	Biological Process	Negative Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1	Retinoid Metabolic Process Ethanol Oxidation Retinol Metabolic Process Retinoic Acid Metabolic Process
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling	Ethanol oxidation
Drugs		Fostamatinib	NADH Fomepizole N-Benzylformamide 4-Iodopyrazole Nicotinamide adenine dinucleotide phosphate Cyclohexanol N-Heptylformamide Glycerin
Diseases
GWAS		Smooth-surface caries ( 24556642) White blood cell count (basophil) ( 29403010)	Adult body size ( 32376654) Alcohol consumption ( 23743675 28937693 31358974) Alcohol consumption (drinkers vs non-drinkers) ( 28485404 31959922) Alcohol consumption (drinks per week) ( 28485404 30643258 31959922 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol consumption in current drinkers ( 28937693) Alcohol dependence ( 24166409 23456092 28714907 31591379 31090166 22004471) Alcohol dependence (desire to cut drinking) ( 31090166) Alcohol dependence (tolerance) ( 31090166) Alcohol dependence symptom count ( 31090166) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Esophageal cancer ( 19698717) Esophageal cancer (alcohol interaction) ( 22960999) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Initial pursuit acceleration ( 29064472) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lung cancer ( 28604730) Maximum habitual alcohol consumption ( 31151762) Metabolite levels ( 23823483) Oral cavity and pharyngeal cancer ( 21437268 27749845) Oral cavity cancer ( 27749845) Oropharynx cancer ( 27749845) Problematic alcohol use ( 32451486) Regular attendance at a pub or social club ( 29970889) Relative fat intake ( 32393786) Relative protein intake ( 32393786) Reticulocyte count ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Urinary sodium excretion ( 31409800)
Interacting Genes		17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6	5 interacting genes: IRAK3 PDE4DIP PML RACK1 SERPINA3
Entrez ID		11213	125
HPRD ID		05123	00065
Ensembl ID		ENSG00000090376	ENSG00000196616
Uniprot IDs		Q9Y616	D6RHZ6 P00325 V9HW50
PDB IDs		5UKE 6RUU 6ZIW	1DEH 1HDX 1HDY 1HDZ 1HSZ 1HTB 1U3U 1U3V 3HUD
Enriched GO Terms of Interacting Partners?
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